Cardioactive, Vasoactive, Sympathomimetics, Sympatholytics
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| Phenylephrine | sympathomimetic (alpha-1 agonist) tx-HT, nasal congestion
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| Beclomethasone | corticosteroid - inhaled (less systemic side effects)
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| Clonidine | sympathomimetic - alpha 2 agonist. tx-HT
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| Theophylline | long acting bronchodilator (phosphodiesterase inhibitor) tx-asthma
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| Terbutaline | sympathomimetic - beta 2 agonist. tx-asthma, emphysema
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| Metoprolol | sympatholytic - beta 1 blocker (agonist) tx-HT
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| Yohimbine | sympatholytic - alpha 2 antgonist. tx-erectile dys. produce mydriasis
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| prazosin | sympatholytic - alpha 1 blocker (antagonist) tx-HT
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| Dobutamine | sympathomimetic - beta 1 agonist. tx-cardiac decomposition
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| Fluticasone | corticosteroid (inhaled) - less systemic side effects
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| Prednisone | corticosteroid (systemic)
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| Four classes of long acting bronchodilators | 1. inflammatory mediators inhibitor 2. beta adrinergic agonists 3. leukotriene antagonists 4. phosphodiesterase inhibitors
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| mediators that actively constrict smooth muscle (4) | histamine, seratonin, platelet activating factor, leukotrienes
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| receptors that NE and Epi act on | beta 1 and 2; alpha 1 and 2 adrinergic receptors
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| receptors that Ach acts on & ultimate effect in the airway | M1 and M2 receptors (smooth muscle contraction in airway)
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| Digoxin | cardiac glycoside - increases contractlity by increasing intracellular [Ca++] tx-heart failure
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| Dopamine | Dopamine agonist low doses: incr. CO, TPR, venous tone. High doses: incr. TPR, pulmonary vascular resistance, produces vasoconstriction
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| positive inotropes | improve cardiac function by increasing contractility. drug classes: beta adrinergic, dopamine agonists, phosphodiesterase inhibitors, cardiac glycosides tx-heart failure
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| cardiac antihypertensives | decrease afterload of heart. beta blockers, Ca++ channel blockers tx-HT, heart failure
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| beta adrinergic agonists - prototype drugs (3) | isoproteronol (B1 and 2), Dobutamine (B1), Terbutaline (B2)
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| Dobutamine | Beta 1 adrinergic agonist (cardioselective) tx-cardiogenic shock, heart failure
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| Terbutaline | Beta 2 adrinergic agonist Tx- asthma, emphysema
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| Isoproteronol | Beta 1 and 2 adrinergic agonist (not cardioselective)
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| Milnirone | phosphodiesterase inhibitor (results in incresed Ca++ release) tx-heart failure, pulmonary problems
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| Brimonidine | sympathomimetic - alpha 2 agonist tx. HT
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| Norephinephrine | alpha 1 agonist - vasoconstrictor tx-hypovolemia
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| prazosin | aplha 1 blocker (causes vasodilation) tx-HT
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| Clonidine | alpha 2 antagonist - sympatholytic - tx-HT
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| Furosemide | Diuretic - decr. blood volume tx-HT, edema, CHF, renal failure
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| positive inotropes | increase contractility to increase BP (classes: Beta adrinergic and dopamine agonists) tx-circulatory shock
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| mecamylamine | ganglionic blocker, nicotinic antagonist tx-severe hypertension (crisis), BP control during aortic surgery
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| Tolcapone | COMT inhibitor - leads to incr. brain [dopamine] tx-parkinsons
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| Verapamil | Ca++ channel blocker (most potent negative chronotrope, inotrope, dromotrope) tx-hypertension
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| Propanolol | B1 and B2 blocker (noncardioselective w/o ISA)
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| Zafirlukast | long acting bronchodilator (anti-inflammatory) blocks leukotriene receptors. tx-asthma
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| Montelukast | long acting bronchodilator (antiinflammatory), leukotriene antagonist tx-asthma
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| Salmeterol | long acting bronchodilator, B2 agonist, tx-asthma
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| Pindolol | B1 and 2 blocker (noncardiselective w/ISA)
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| Atenolol | B1 blocker (cardioselective w/o ISA)
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| Acebutolol | B1 blocker (cardioselective w/ISA)
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| Propanolol | B1 and B2 blocker (NON cardioselective) tx-HT
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| Atropine | Anthicholinergetic (muscarinic antagonist) tx-produce mydriasis, decr. airway secretions during intubation
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| Tolterodine | anticholinergic (muscarininc antagonist) tx-overactive bladder
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| Sites of adrinergic drug action (6) | 1. synthesis 2. vesicular packaging 3. release 4. receptor binding 5. re-uptake 6. metabolism
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| Metyrosine | blocks synthesis of NE tx-pheocromacytoma (causes HT)
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| Reserpine | blocks vesicular packaging of NE tx-Ht
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| Desipramine | TriCyclicAntidepressant: blocks reuptake of NE tx-depression
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| Isocarboxazid | MAO inhibitor: inactivates excessice neurotransmitters tx-depression
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| Demecarium | cholinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, open angle glaucoma
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| Ambenonium | chlinergic (indirect) agonist - inhibits acetylcholinesterase tx-myasthenia gravis, glaucoma
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| Pilocarpine | Cholinomimetic (Ach agonist) Tx-occular HT, glaucoma
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| Albuterol | B agonist: rapid acting bronchodilator tx-asthma
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| Ipratropium bromide | Anticholinergic - rapid acting bronchodilator Tx-asthma
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| Pancuronium | ganglionic blocker, Ach antagonist Tx-hypertensive crisis, control in surgery on aortic aneurism/surgery on blood vessels
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| cardiac effects of Ach | parasympathetic response (decr. HR, Decr. contractility) MOA-activation of K+ channels, inhibittion of Ca++ channels, adenylyl cyclase
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| Cardiac effects of NE/Epi | sypathetic response - incr. HR, inr. contractility MOA - activate adenyly cyclase, activate Ca++ channels
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| Sundilac | anaglesic, antipyretic, anti-inflammatory. Active sulfide metabolite.
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| Ketorolac | analgesic in ER for suspected opiod users, available in parenteral form
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| DMARD stands for? | Disease Modifying Anti Rheumatoid arthritis Drugs
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| Methotrexate | synthetic DMARD. Tx-RA
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| Infliximab | biological DMARD, inhibits TNF-alpha (inflammatory mediator)
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| Anakinra | inhibits IL-1 tx-RA
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