Inflammation: Repair, Regeneration, and Fibrosis
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| what is the major extracellular structural protein | collagen
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| Where is type I collagen found | skin, bone, tendons, mature scars
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| where is type III collagen found | blood vessels, uterus, GI, early wound healing
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| what forms the basement membrane | laminin and type IV collagen
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| what transmembrane glycoproteins are involved in cell-cell and cell-matrix adhesion and recognition | integrins and selectins
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| what extracellular matrix structural comonents serve to regulate permeability | proteoglycans
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| what polymer is an important ligand for core proteins, binds H20 providing tissue turger | Hyaluronan
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| what are the four sequential parts of wound healing | thrombus, inflammation, granulation, fibroblast proliferation and matrix accumulation
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| how do growth factor receptors trigger secondary signalling | self-phosphorylation through GTP binding proteins (ras and G protein) and phospholipase C-8
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| what growth factors stimulate angiogenesis | fibroblast growth factor and vascular endothelial growth factor
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| what growth factor is important for vasculogenesis and angiogenesis | Vascular Endothelial Growth Factor (VEGF)
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| what growth factor is found in saliva, sweat, urine, and GI secretions? | Epidermal Growth Factor
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| what growth factor is an inhibitor of most epithelial cell growth but enhances collagen synthesis | TGF-B
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| what percent of tissue strength is recovered after wound healing | 70-80%
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| What are some examples of Labile Tissue | tissue that proliferates throughout life (skin, GI, Marrow)
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| What are some examples of Stable Tissues | low rate of replication (Liver, Kidney, Pancreas, Bone)
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| What are some examples of Permanent Tissues | no postnatal division (neurons-skeletal and cardiac)
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| Systemic conditions that may modify repair | Nutritional deficiencies, diabetes, glucocorticosteroids, antibiotics, hypovolemia, anemia, hypoxia
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| what is healing by first intention | this is a primary union seen with clean surgical incision wounds with limited tissue damage
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| at what day to macrophages predominate with wound healing | by day 3
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| when do you see well-formed granulation tissue with wound healing | by day 5-7
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| when do you see a scar following wound healing | 1 month to 1 year
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| what is second intention healing | when the wound is not a clean surgical incision characterized by intense inflammation and a large amount of granulation tissue
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| what is exuberant granulation | excess granulation tissue
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| what is keloid | excess collagen production results in a hypertrophic scar
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| what is a contracture | excesive contraction
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| what do you see when there is inadequate scar formation | wound dehiscence and ulceration
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| what part of the nervous system may regenerate axons | peripheral NS
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| Wounds from what fetal period show no scar | from the first and second trimester
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