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Path 3

Inflammation: Repair, Regeneration, and Fibrosis

what is the major extracellular structural protein collagen
Where is type I collagen found skin, bone, tendons, mature scars
where is type III collagen found blood vessels, uterus, GI, early wound healing
what forms the basement membrane laminin and type IV collagen
what transmembrane glycoproteins are involved in cell-cell and cell-matrix adhesion and recognition integrins and selectins
what extracellular matrix structural comonents serve to regulate permeability proteoglycans
what polymer is an important ligand for core proteins, binds H20 providing tissue turger Hyaluronan
what are the four sequential parts of wound healing thrombus, inflammation, granulation, fibroblast proliferation and matrix accumulation
how do growth factor receptors trigger secondary signalling self-phosphorylation through GTP binding proteins (ras and G protein) and phospholipase C-8
what growth factors stimulate angiogenesis fibroblast growth factor and vascular endothelial growth factor
what growth factor is important for vasculogenesis and angiogenesis Vascular Endothelial Growth Factor (VEGF)
what growth factor is found in saliva, sweat, urine, and GI secretions? Epidermal Growth Factor
what growth factor is an inhibitor of most epithelial cell growth but enhances collagen synthesis TGF-B
what percent of tissue strength is recovered after wound healing 70-80%
What are some examples of Labile Tissue tissue that proliferates throughout life (skin, GI, Marrow)
What are some examples of Stable Tissues low rate of replication (Liver, Kidney, Pancreas, Bone)
What are some examples of Permanent Tissues no postnatal division (neurons-skeletal and cardiac)
Systemic conditions that may modify repair Nutritional deficiencies, diabetes, glucocorticosteroids, antibiotics, hypovolemia, anemia, hypoxia
what is healing by first intention this is a primary union seen with clean surgical incision wounds with limited tissue damage
at what day to macrophages predominate with wound healing by day 3
when do you see well-formed granulation tissue with wound healing by day 5-7
when do you see a scar following wound healing 1 month to 1 year
what is second intention healing when the wound is not a clean surgical incision characterized by intense inflammation and a large amount of granulation tissue
what is exuberant granulation excess granulation tissue
what is keloid excess collagen production results in a hypertrophic scar
what is a contracture excesive contraction
what do you see when there is inadequate scar formation wound dehiscence and ulceration
what part of the nervous system may regenerate axons peripheral NS
Wounds from what fetal period show no scar from the first and second trimester
Created by: UVAPATH1



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