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Path 3
Inflammation: Repair, Regeneration, and Fibrosis
| Question | Answer |
|---|---|
| what is the major extracellular structural protein | collagen |
| Where is type I collagen found | skin, bone, tendons, mature scars |
| where is type III collagen found | blood vessels, uterus, GI, early wound healing |
| what forms the basement membrane | laminin and type IV collagen |
| what transmembrane glycoproteins are involved in cell-cell and cell-matrix adhesion and recognition | integrins and selectins |
| what extracellular matrix structural comonents serve to regulate permeability | proteoglycans |
| what polymer is an important ligand for core proteins, binds H20 providing tissue turger | Hyaluronan |
| what are the four sequential parts of wound healing | thrombus, inflammation, granulation, fibroblast proliferation and matrix accumulation |
| how do growth factor receptors trigger secondary signalling | self-phosphorylation through GTP binding proteins (ras and G protein) and phospholipase C-8 |
| what growth factors stimulate angiogenesis | fibroblast growth factor and vascular endothelial growth factor |
| what growth factor is important for vasculogenesis and angiogenesis | Vascular Endothelial Growth Factor (VEGF) |
| what growth factor is found in saliva, sweat, urine, and GI secretions? | Epidermal Growth Factor |
| what growth factor is an inhibitor of most epithelial cell growth but enhances collagen synthesis | TGF-B |
| what percent of tissue strength is recovered after wound healing | 70-80% |
| What are some examples of Labile Tissue | tissue that proliferates throughout life (skin, GI, Marrow) |
| What are some examples of Stable Tissues | low rate of replication (Liver, Kidney, Pancreas, Bone) |
| What are some examples of Permanent Tissues | no postnatal division (neurons-skeletal and cardiac) |
| Systemic conditions that may modify repair | Nutritional deficiencies, diabetes, glucocorticosteroids, antibiotics, hypovolemia, anemia, hypoxia |
| what is healing by first intention | this is a primary union seen with clean surgical incision wounds with limited tissue damage |
| at what day to macrophages predominate with wound healing | by day 3 |
| when do you see well-formed granulation tissue with wound healing | by day 5-7 |
| when do you see a scar following wound healing | 1 month to 1 year |
| what is second intention healing | when the wound is not a clean surgical incision characterized by intense inflammation and a large amount of granulation tissue |
| what is exuberant granulation | excess granulation tissue |
| what is keloid | excess collagen production results in a hypertrophic scar |
| what is a contracture | excesive contraction |
| what do you see when there is inadequate scar formation | wound dehiscence and ulceration |
| what part of the nervous system may regenerate axons | peripheral NS |
| Wounds from what fetal period show no scar | from the first and second trimester |
Created by:
UVAPATH1
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