Glycolysis
Quiz yourself by thinking what should be in
each of the black spaces below before clicking
on it to display the answer.
Help!
|
|
||||
|---|---|---|---|---|---|
| show | - process that cleaves and oxidizes glucose
-ultimate goal to produce ATP, pyruvate and NHDA
-happen in cytosol of all cell
-required for production of energy from glucose(ananerobic or aerobic cell)
🗑
|
||||
| show | Glucose, ADP, NAD+
🗑
|
||||
| how does glucose enter the cell? | show 🗑
|
||||
| Which cell has high affinity transporter with large amount of transporters on the cell surface? | show 🗑
|
||||
| show | LIVER
🗑
|
||||
| Which cell or tissue has insulin sensitive transporters and little amount on cell surface? | show 🗑
|
||||
| show | Hexokinase
different isoform (Liver ==> Glucokinase , hexokinase IV)
brain: hexokinase I
🗑
|
||||
| how does a cell trap glucose? | show 🗑
|
||||
| What is the name of hexokinase used by Liver | show 🗑
|
||||
| show | Liver and muscle
brain hexokinase is not regulated by insulinas brain is highly depend on glucose
🗑
|
||||
| show | Muscle has no receptor for glucagon
🗑
|
||||
| 3 pathway that glucose-6-phosphate can proceed to | show 🗑
|
||||
| which enzyme catalyze following process fructose 6-phosphate ==> fructose 1,6-biphosphate | show 🗑
|
||||
| show | Activation factor: AMP
Inhibition factor: ATP
🗑
|
||||
| Which two products does fructose 1,6-biphosphate split into? | show 🗑
|
||||
| What enzyme catalyze the formation of pyruvate and from which molecules? | show 🗑
|
||||
| show | upregulated by Insulin (liver and muscle)
downregulated by Glucagon (Liver only)
🗑
|
||||
| what are the two product formed from Pyruvate | show 🗑
|
||||
| can NADH cross from cytoplasm to mitochondrion? | show 🗑
|
||||
| What are the two ways to regenerate NAD+ | show 🗑
|
||||
| where does the conversion of pyruvate to acetyl coA happen in cell? is it a reversible or irreversible process? | show 🗑
|
||||
| What enzyme catalyze process of conversion of pyruvate to acetyl coA? | show 🗑
|
||||
| What activate the activity of PDC? | show 🗑
|
||||
| show | elevation of ATP, CoA-acetyl, NADH and absence of O2
🗑
|
||||
| what is the key rate limiting enzyme in TCA cycle? | show 🗑
|
||||
| TCA Cycle | show 🗑
|
||||
| What vitamin derived cofactor is required by TCA cycle and PDC activity? | show 🗑
|
||||
| show | -nutritional deficiencies
-Ischemia/hypoxia
🗑
|
||||
| show | It can replenish from Pyruvate with the help of pyruvate carboxylase.
🗑
|
||||
| show | fatty acid, ketones, amino acid, alcohol
TCA cycle is a must to generate ATP from them
🗑
|
||||
| show | Pyruvate ==> Oxaloacetate=> citrate => isocitrate => alpha-ketoglutarote => succinyl coA => succinate => fumarate => malate => oxaloacetate
🗑
|
||||
| show | fatty acid syntheis
🗑
|
||||
| show | heme synthesis
🗑
|
||||
| What is the rate limiting process in TCA cycle? | show 🗑
|
||||
| product of TCA Cycle | show 🗑
|
||||
| show | Mitochondrion
It is synthesized in mitochondrion but it cannot across the Mitochondrial membrane
🗑
|
||||
| show | Citrate, so it can move out into cytosol where fatty acid synthesis occurs
🗑
|
||||
| show | 1) Hexokinase (glucokinase in liver)
2) Phosphofructokinase
3) Pyruvate kinase
🗑
|
||||
| Phosphofructokinase -2 (PFK-2) | show 🗑
|
||||
| which enzyme promote the synthesis of glycagon | show 🗑
|
||||
| show | Glucogen phosphorylase + debranching enzyme
🗑
|
||||
| show | -ONLY in Liver
-convert glucose 6-phosphate to glucose and export out of cell
muscle lack of this enzyme and cant transport glucose out of cell
🗑
|
||||
| show | Tyrosine kinase receptor
🗑
|
||||
| show | GPCR (G-protein coupled receptor)
🗑
|
||||
| show | glucose-1-phosphate ==> UDP-glucose ==> Glycogen
enzyme: glycogen synthase, branching enzyme)
🗑
|
||||
| show | glycagon ==> glucose-1-phosphate
enzyme: glycogen phosphorylase, debranching enzyme
🗑
|
||||
| What activate glucogen synthase activity? | show 🗑
|
||||
| show | Glucagon (exception muscle)
epinephrine
🗑
|
||||
| What activate glucogen phosphorylase activity? | show 🗑
|
||||
| show | Insulin
🗑
|
||||
| show | 1) the need for ATP
2) whether or not the muscle is exercising (level of calcium)
🗑
|
||||
| slow twitch fiber vs fast twitch fiber | show 🗑
|
||||
| Myoglobin | show 🗑
|
||||
| what type of muscle fiber does muscle involve in posture usually have? | show 🗑
|
||||
| show | Fast twitch fiber
🗑
|
||||
| Cardiac muscle | show 🗑
|
||||
| show | The length of fast
🗑
|
||||
| show | it increases skeletal muscle break down and conversion of amino acid to glucose
🗑
|
||||
| Creatine | show 🗑
|
||||
| show | -enzyme express in muscle cell
-2ADP==> 1 ATP + 1 AMP
🗑
|
||||
| Which pathway is the primary way that skeletal muscle obtains its ATP at the onset of exercise | show 🗑
|
||||
| Anaerobic glycolysis | show 🗑
|
||||
| Cori Cycle | show 🗑
|
||||
| show | -present high amount in skeltal and cardiac muscle
increase AST ==> Tissue damage
🗑
|
||||
| show | Brain; 2 B subunit (CK-BB_
Muslce; 2 M subunit (CK-MM)
Cardiac muscle: 1 M and 1 B subunit (CK-MB)
🗑
|
||||
| show | -breakdow product of damaged muscle tissue release into blood stream
-increase in creatinine level
🗑
|
||||
| show | inflammatrion of cell
🗑
|
||||
| what happen to the level of creatinine in a person with loss of muscle | show 🗑
|
Review the information in the table. When you are ready to quiz yourself you can hide individual columns or the entire table. Then you can click on the empty cells to reveal the answer. Try to recall what will be displayed before clicking the empty cell.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
To hide a column, click on the column name.
To hide the entire table, click on the "Hide All" button.
You may also shuffle the rows of the table by clicking on the "Shuffle" button.
Or sort by any of the columns using the down arrow next to any column heading.
If you know all the data on any row, you can temporarily remove it by tapping the trash can to the right of the row.
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.
Normal Size Small Size show me how
Normal Size Small Size show me how
Created by:
powerbaby
Popular Medical sets