Question | Answer |
abl | CML, oncogene |
c-myc | burkitt's lymphoma, oncogene |
bcl-2 | follicular and undifferentiated lymphoma (inhibits apoptosis), oncogene |
erb-B2 | breast, ovarian, and gastric carcinoma, oncogene |
ras | colon carcinoma, oncogene |
L-myc | Lung tumor, oncogene |
N-myc | Neuroblastoma |
ret | multiple endocrine neoplasia (MEN) types I and II, oncogene |
Rb | chrom 13q, tumor suppressor, retinoblastoma, osteosarcoma. suppresses G1 -->S by inactivating EF2 |
BRCA 1 and 2 | 17q, 13q. tumor suppresor gene, breast and ovarian cancer |
p53 | 17p, tumor suppressor gene, activates apoptosis, most human cancers, Li-Fraumeni syndrome |
p16 | 9p, tumor suppressor gene, melanoma |
APC | 5q, tumor suppressor gene, colorectal cancer |
WT1 | 11q, Wilms' tumor, tumor suppressor gene |
NF1 | 17q, tumor suppressor gene, Neurofibromatosis type 1 |
NF2 | 22q, tumor suppressor gene, Neurofibromatosis type 2 |
DPC | 18q, tumor suppressor gene, pancreatic cancer |
DCC | 18q, tumor suppressor gene, colon cancer |
PSA (prostatic acid phosphatase) | prostate specific antigen, prostatic carcinoma, used for screening |
CEA | carcinoembyronic antigen. very nonspecific but make by about 70% of colorectal and pancreatic cancers; also produced by gastric and breast carcinomas |
a-fetoprotein | fetus (normal). hepatocellular carcinomas. nenseminomatous germ cell tumors of the testis (eg yolk sac tumor) |
B-hCG | Hyaditidorm mole, choriocarcinoma, gestational trophoblastic tumors |
CA-125 | ovarian, malignant epithelial tumors |
S-100 | melanoma, neural tumors, astrocytoma |
alkaline phosphatase | metastases to bone, obstructive biliary disease, Paget's disease of bone |
bombesin | neuroblastoma, lung and gastric cancer |
TRAP | Tartrate-resistant acid phosphatase. hair cell leukemia, a B cell neoplasm |
t(9;22) | Philadelphia chromosome, CML (bcr-abl hybrid) |
t(8;14) | Burkitt's lymphoma, c-myc activation |
t(14;18) | follicular lymphoma (bcl-2 activation) |
t(15;17) | M3 type of AML (responsive to all trans retinoic acid). translocation of retinoic acid receptor |
t(11;22) | Ewing's sarcoma |
t(11;14) | Mantle cell lymphoma. overexpression of cyclins rushes cell through cycle and results in hyperproliferation. |
Hodgkin's therapy ABVD | adriamycin (doxorubicin), bleomycin, vincristine, dexamethasone |
Hodgkin's therapy MOPP | mustard, oncovin (vincristine), procarbazine, prednisone |
T cell marker | CD 1-8 |
B cell marker | CD 10, 19-23 |
Mono, mac marker | CD 13, 14, 15, 33 |
Stem cell | CD 34 |
ALL marker | CD 45 |
NK marker | CD 16, 56 |
B Cell ALL marker | CD 10, 19, 20 |
T Cell ALL Marker | CD1 and Pan T |
CLL marker | CD 5, 23 |