Question | Answer |
what N. Men capsules cause meningitis | A, B, C |
what does Endotoxin LPS do? | releases endotoxin for blood vessel distruction |
how does Endotoxin LPS do? | causes petechial rash and may cause damage to adrenals |
what does IgA protease do? | cleaves IgA in two |
What does Iron clavage factor do? | gets iron from human transferrin |
what percent of the population has asymptomatic carriage of n. meingitis | 5-10% |
what are the virulence factors of N. Meningitis | Capsule, Endotoxin LPS, IgA1 protease, Iron cleavage |
Acute purulent meningitis is what percent of percentage of meningitis are acute purulent | 20% |
what causes acute purulent meningitis | serotype b |
Acute bacterial meningitis has a mortality of? | 10-15% |
Meningococcemia is caused by | Disseminated intravascular coagulation DIC |
Waterhouse fredrichsen syndrome is ? | N. men causes bilateral hemorrhagic destruction of the adrenals and shock |
what causes chronic meningococcemia | transient bacteremia by Serotype Y |
how do you treat N. Meningitis infection | My need reconstructive surgery, pen G, cephalosporin (gets meninges) and rifampin for prophylaxis |
vaccines for N. Meningitis | Menomune against A, C, Y, W-135 NOT B |
why is there no vaccine against Serotype B neisseria meningitis | because it has a sialic acid capsule which is self-like |
how does N. Meningitis initially colonize? | Pili (sticks its nose in) |
How does N. meningitis get closer? | opa protein |
what part of N. Meningitis interferes with prolonged carriage | capsule and pili prevent extremely close attachment (get in the way) but they are essential |
how long does it take to launch an Ab response to N. Meningitis? | 7-10 days |
what does N. Meningitis grow on | Thayer martin or chocholate agar |
what temp does. N. meningitis like? | 35-37 |
catalase status | positive |
oxidase status | positive |
how many serotypes are there of n. meningitis | 16 |
how can you diagnose n. meningitis | Thayer martin plates, latex bead agglutination, CSF or Blood culture |
what polysaccharide capsule is common in africa | Group A |
what capsule is common in the US | Group B and C |
what is special about Group B capsule | it is sialic acid (non-immunogenic) |
what is special about Group C capsule | antiphagocytic |
how does N. meningitis avoid the immune system | capsule and opa/pili variation |
where does N. meningitis bind | non-ciliated cells of the Nasopharynx |
what causes the symptoms of N. meningitis | LOS activated coagulation system |
what can you do to encourage Neiserria growth | add CO2 |
what are two signs of n. meningitis in infants | bulging fontenelles and kernigs brudzinski's sign |
waht does vancomycin kill | gram positive |
what does colistin kill | all gram neg. but neisseria |
what does nystatin kill | fungi |
how can you tell n. men from n gon | maltose fermentor |