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BACT: N. Meningitis
DD
| Question | Answer |
|---|---|
| what N. Men capsules cause meningitis | A, B, C |
| what does Endotoxin LPS do? | releases endotoxin for blood vessel distruction |
| how does Endotoxin LPS do? | causes petechial rash and may cause damage to adrenals |
| what does IgA protease do? | cleaves IgA in two |
| What does Iron clavage factor do? | gets iron from human transferrin |
| what percent of the population has asymptomatic carriage of n. meingitis | 5-10% |
| what are the virulence factors of N. Meningitis | Capsule, Endotoxin LPS, IgA1 protease, Iron cleavage |
| Acute purulent meningitis is what percent of percentage of meningitis are acute purulent | 20% |
| what causes acute purulent meningitis | serotype b |
| Acute bacterial meningitis has a mortality of? | 10-15% |
| Meningococcemia is caused by | Disseminated intravascular coagulation DIC |
| Waterhouse fredrichsen syndrome is ? | N. men causes bilateral hemorrhagic destruction of the adrenals and shock |
| what causes chronic meningococcemia | transient bacteremia by Serotype Y |
| how do you treat N. Meningitis infection | My need reconstructive surgery, pen G, cephalosporin (gets meninges) and rifampin for prophylaxis |
| vaccines for N. Meningitis | Menomune against A, C, Y, W-135 NOT B |
| why is there no vaccine against Serotype B neisseria meningitis | because it has a sialic acid capsule which is self-like |
| how does N. Meningitis initially colonize? | Pili (sticks its nose in) |
| How does N. meningitis get closer? | opa protein |
| what part of N. Meningitis interferes with prolonged carriage | capsule and pili prevent extremely close attachment (get in the way) but they are essential |
| how long does it take to launch an Ab response to N. Meningitis? | 7-10 days |
| what does N. Meningitis grow on | Thayer martin or chocholate agar |
| what temp does. N. meningitis like? | 35-37 |
| catalase status | positive |
| oxidase status | positive |
| how many serotypes are there of n. meningitis | 16 |
| how can you diagnose n. meningitis | Thayer martin plates, latex bead agglutination, CSF or Blood culture |
| what polysaccharide capsule is common in africa | Group A |
| what capsule is common in the US | Group B and C |
| what is special about Group B capsule | it is sialic acid (non-immunogenic) |
| what is special about Group C capsule | antiphagocytic |
| how does N. meningitis avoid the immune system | capsule and opa/pili variation |
| where does N. meningitis bind | non-ciliated cells of the Nasopharynx |
| what causes the symptoms of N. meningitis | LOS activated coagulation system |
| what can you do to encourage Neiserria growth | add CO2 |
| what are two signs of n. meningitis in infants | bulging fontenelles and kernigs brudzinski's sign |
| waht does vancomycin kill | gram positive |
| what does colistin kill | all gram neg. but neisseria |
| what does nystatin kill | fungi |
| how can you tell n. men from n gon | maltose fermentor |
Created by:
jmuame03
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