Question | Answer |
What is the kidneys function? | 1)excretion of metabolic waste products and foreigen chemicals 2)regulation of water,electrolyte,osmolality, electrolyte concentration 3)reg. acid-base balance 4)reg. arterial pressure 5)hormone sec. 6)gluconeogenesis |
What kind of waste products? | Urea, creatine, uric acid, bilirubin, metabolic wastes, things not needed by body and toxins. |
Describe the renal blood supply. | Renal arterie-> |
What is a nephron? | Kidneys functional unit includes glomerule, bowmanscapsel and tubule |
Descibe the different between cortical and juxtamedullary nephorns! | Cortical<-cortex, Juxtamedullary<-medulla - vasa recta (supplies medulla with nutrition)- concentrates the urine |
Urinary formation is a result of? | Glomerule filtration, tubular reabsorbtion and tubuar secretion. |
Why is secretion important? | It determents the amount of K and H excreted in urine. |
Why does our body filtrate a large amount of fluid and then reabsors it? | 1) to be able to remove wastes fast 2)high GFR allow all fluid to be filtred and processed many time per day (60X) |
What does the filtrated fluid contain? | Its has the same organic and solute concentration as plasma but absent of protien. |
What is not filtered? | Ca and fatty acids and large particles. |
How many precent of renal plasma is filtered? | 20% |
What is the filtration fraction? | Ff=Gfr/renal plasma flow (0,2=120/600) |
What does increased Ff lead to? | (blank) |
What happens when glomerular cap hydrostatic pressure changes? | increased HP->Inc. GFR | decreased HP->decreased GFR |
What is glomerular hydrostatic pressure determined by? | 1)Arterial pressure 2)aff. arteriol resistens 3) efferent arteriol resistens |
What happens when you change things that determins hydrostatic pressure? | incr. arteriol pressure->incr. GFR | incr. affer resistens->decr. GFR | incr. efferent resistens->incr.GFR (But to much->decr. GFR) |
Describe the filtration barrier! | 1) endothelial, fenestrated 2)basmentmembrane 3)podocytes |
Explain why negatibly charged molecules have difficulty passing the filtration barrier! | Because of the negative charge barrier in basment and podocytes. |
What determents GFR? | GFR=Kf X (Pg-Pb-Cg+Cb) (125=12,5x(60-18-32+10)) |
Increased bowman's capsule hydrostatic pressure leads to? | Stones->increased pressure-->decreased GFR->damages kidney |
Increased glomerular capillary colloid osmotic pressure leads to? | Decreased GFR, (without this force all plasma would be filtrated) |
Why does the glomerular capillary colloid osmotic preussure rise from afferent to efferent arteriol? | Because of filtration which leads to incr. glomerular colloid osmotic pressure (more protiens then before) |