Question | Answer |
When does renewal occur | in cases where we loose our cells naturally (intestines lining, skin, etc..) |
When is regeneration of cells no longer able to occur | when parenchymal cells are lost |
What role do endothelial cells play in repair | they participlate in angiogenesis and thus facilitate bring blood flow back to the area |
What role do PMN's and macrophages play in repair | remove damage tissue and prevent infection |
What role to parenchymal cells play in repair | regenerate tissues with the primary functional cell type |
Are parencymal cells found in the heart? | NO |
What are charactestics of type I collagen | really strong and found in late wound healing |
Where would you find type IV collagen | in the basement membrane |
What are 2 traits of type III collagen | found in early wound healing and is fairly weak |
What happens in Hemostasis | fibrinogen is converted to fibrin |
What is a provisional matrix | this is an early/temporary cellular matrix that supports cellualr migration. |
Which collagen type is found in a provisional matrix | type 3 |
Which cell types are found in granulation tissue | monocytes, plasma cells, and macrophages |
During re-epithelialization what is occuring | parenchymal cell recovery |
What structure/cell type is responsible for contraction | myofibroblast |
What day does contracture usually occur | day 3 |
Which collagen type helps to regain tissue strength | type I |
Which type of tissue is vascular, resistent to infection, occurs between inflammation and contracture and secretes collagen? | granular tissue |
Which type of wound intention lends itself to fibrosis, less dense tissue and poor reapproxiamtion | secondary |
What are the three major influences on wound repair | Location, nature/amount of ECM, and Blood supply |
Will the kideny regenerate if there is minimal damage to the ECM | yes |
Which area of the kidney is most sussceptible to injur | medulla |
Which process occurs when there is chronic injury to the liver | fibrosis |
Do glomeruli regenerate | NO |
How do lung cells regenerate | Type 2 --> Type 1 |
What does a patchy loss of cells in the heart signify | interstital fibrosis which could lead to cardiomyopathy or ishemic heart disease |
A difuse loss of cells in the heart signals what | myocardial infarction |
What type of necrosis follows and MI | coagulative |
Which type of nuerons have the ability to regenerate | PNS |
What type of cells do the scarring in the PNS | fibroblast |
Abnormal/pathologic contractures can cause bowel stricture if they occur where | abdomen |
A exuberant, disorganized deposition within the dermis that extends beyond the anatomic boundries of of normal sturcture is called what | Keloid |
Who is at risk for keloids | darker skined indivudals |
What is excessive scar formation referred to as | hypertrophic scars |
Which areas are prone to pathologic contractures | palms and shoes |
Are contractures common following burns | yes |
What is a pyogenic ganuloma | exuberant overgrowth of granulation tissue |
When are pyogenic granulomas likely to occur | on the gingiva of pregnant women |
granulation tissue that extends above the epithelial surface and precludes re-epithelialization is called what | proud flesh |
What is excessive, persistent fibrosis following an injury or surgical incision called | desmoids |