Question | Answer |
Immunology | |
Immunity | |
Innate Resistance | |
Monocytes / Macrophages | |
Granulocytes | |
Neutrophils. | |
Eosinophils | |
Natural Killer Cells | |
Chemotaxins | |
Opsonin | |
Defensins | |
Oxidative Burst | |
Probiotics | |
Prebiotics | |
Granulocytic Phagocytes | |
Zymogens | |
Differentiate
First (barrier or external), second, and third (adaptive or acquired) lines of defense against infectious disease. | |
Differentiate
Inducible vs noninducible defense mechanisms | |
Discuss
characteristics of an immune response (specificity, memory, recognition) | |
Discuss
mechanisms involved in the first line of defense | |
Discuss
benefits vs disadvantages of iron supplements in terms of host defenses | |
Discuss
hygiene hypothesis and its role in immune response | |
Discuss
molecules involved in the attachment of PMNs to endothelial cells | |
Discuss
suspected relations between CRP and heart disease | |
Discuss
complement activation | |
Discuss
the effects of complement act INSERT | |
Discuss
the complement regulatory mechanisms | |
Discuss
clinical features that ELEVATE complement protein concentrations | |
Discuss
clinical features that DECREASE complement protein concentrations | |
Compare
four types of acquired immunity (eg active natural immunity) | |
Compare
roles physiologic factors have on host defense | |
Compare
classical, alternative, and lectin pathways of complement activation, including mode of activation, proteins involved, etc. | |
Contrast
cellular and humoral components of the innate immune responses | |
Evaluate
role of defensins in host protection against infectious diseases | |
Evaluate the roles of macrophages and neutrophils in inflammation and phagocytosis | |
Evaluate the complement system in protection again infectious diseases | |
Describe the role of toll-like receptors in innate immunity | |
Describe the role of normal microbiota in protection against infection | |
Describe the sites and cells in the mononuclear phagocytic system | |
Describe granulocytic phagocytes | |
List examples of mononuclear cells | |
Describe how phagocytes kill bacteria, including the role of the oxidaivete burst | |
Arrange the events of phagocytosis in order from activation of cells to killing of bacteria | |
List examples of opsonins | |
Describe the key features of the inflammatory response | |
List proteins that are referred to as acute phase reactants | |
Explain the principle of the c-reactive protein (CRP) test and cite advantages over the erythrocyte sedimentation rate (ESR) as an indicator of inflammation | |
Explain the use of CRP for monitoring the course of a disease | |
Explain why the activation of complement INSERT STUFF | |
Describe C3 convertase and C5 convertase in both the classical and alternative complement pathways. | |
Identify the two major amplification steps in the classical complement cascade | |
Identify the complement components in the membrane attack complex (MAC) | |
Describe how the MAC causes lysis of target cells | |