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NMB Pharm

Y2- NMB Unit Pharm MOA

QuestionAnswer
Phenytoin (Dilantin) Selectively binds to inactivate Na+ channels and decrease Glutamate release from excitatory presynaptic neurons.
Carbamazapine Stabilizes the inactivated state of Na+ channels. Potentiate GABA receptors.
Lamotrigine Blocks voltage gated Na+ channels. Decrease release of Glutamate from excitatory NTs
Valproic acid Increase Na+ channel inactivation. Inhibits GABA transaminase
Gabapentin Binds to presynaptic N-type Ca++ channels. Decrease NT Release
Topiramate Block voltage gated Na+ channels. Antagonize AMPA/kainate glutamate receptors.
Phenobarbital Bind GABAa receptor and prolong duration of CL- channel opening
Ethosuximide Blocks thalamic T-type Ca++ channels.
Lorazepam (Benzo) Diazepam bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening.
Short Acting (highest addiction potential) triazolam, oxazepam, alprazolam, midazolam bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
Medium Acting estazolam, lorazepam, temazepam bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
Long Acting (greatest fall risk) chlordiazepoxide, diazepam, flurazepam, clonazepam, clorazepate bind GABAa receptor at interface of alpha and gamma subunits. Increase frequency of of GABA binding and increased frequency of chloride channel opening. Fix OD with Flumenazil
Tigabine Selective GABA reuptake inhibitor
Vigabatrin Irreversibly inhibit GABA transaminase
Levetiracetam Inhibit voltage dependent N=type Ca++ channels. Bind to synaptic proteins that modulate neurotransmitter release.
Oxycarbazepine Na+ channel blocker
Felbamate Has an effect on GABA receptor binding sites
Lacosamide Enhance slow activation of Na+ channels and interacts with CRMP-2
Rufinamide Prolongs the inactivation state of the Na+ channel
Sulthiame Carbonic anhydrase inhibitor
Zonisamide Binds Na+ channels, Voltage sensitive Ca++ channels, partial CAI
Created by: rhinorat21