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Haem & Derm pharma
Medications used in haem and derm logbooks
Question | Answer |
---|---|
Benzoylperoxide | Acne Direct antimicrobial & action as peeling agent by increasing skin turnover, decreasing comodome formation. Topical treatment First line treatment |
Isotretinoin / Roaccutane | Acne Retinoid (Vit A derivative) - Oral or Topical Induces apoptosis of sebum glands and antimicrobial action on propionibacterium acnes Topical - Adapalaene Systemic - Roaccutane Oral - dry skin lips eyes. Teratogenic. Liver damage. Depression |
Tetracycline | Acne or Rosacea Topical antibiotic Works directly on propionibacterium acnes. Protein synthesis inhibitor, blocks tRNA - bacteriostatic. Can cause photosensitisation Contraindicated in pregnancy and children under 12 (deposited in bone/teeth) |
Erythromycin | Acne Topical antibiotic Macrolide antibiotic Inhibits protein synthesis and has bactericidal effect at high concentrations. |
Cyproterone | Acne Anti-androgen - WOMEN ONLY Reduces systemic androgen production - reducing sebum production. |
Metronidazole | Rosacea Anaerobes and Protozoa Inhibits enzymes and DNA synthesis |
Dermol 500 | Eczema & Psoriasis Emollient, soap substitute and bath oil Antimicrobial action Forms barrier over skin reducing water loss. Aids water retention. |
Hydromol | Eczema & Psoriasis Urea containing humactant. Moisturising effect and urea draws fluid into tissue. |
Doublebase & Diprobase | Eczema & Psoriasis Moisturising effect. No antimicrobial action |
Coal Tar | Psoriasis & Seborrhoeic dermatitis Coal Tar Often used on scalps Anti-inflammatory properties and keratolytic effects. Skin irritation and staining. |
Hydrocortisone | Mild topical steroid. Eczema & Psoriasis Immunosupression, reduction of inflammation. Skin thinning, telangiectasia, easy bruising, striae. 0.5% only on faces. Up to 2.5% elsewhere |
Eumovate | Moderate Topical steroid Eczema & Psoriasis Immunosupression, reduction of inflammation. Skin thinning, telangiectasia, easy bruising, striae. DO NOT USE ON FACES |
Betnovate | Potent Topical steroid Eczema & Psoriasis Immunosupression, reduction of inflammation. Skin thinning, telangiectasia, easy bruising, striae. DO NOT USE ON FACES |
Dermovate | Ultra Potent Topical steroid Eczema & Psoriasis But beware unstable psoriasis Immunosupression, reduction of inflammation. Skin thinning, telangiectasia, easy bruising, striae. DO NOT USE ON FACES |
Tacrolimus | Topical Calcineurin inhibitor Steroid sparing agent Eczema Immunosuppressant but doesn't cause skin atrophy. Can use on face |
Ciclosporin | Oral Calcineurin inhibitor Steroid sparing agent Eczema Immunosuppressant but doesn't cause skin atrophy. Can use on face |
Patch Testing | Irritant dermatitis or eczema Patches applied with control and "read" 48 hrs and a week later. |
Pin Prick Testing | Allergen test for hypersensitivity reaction. "Read" at 15minutes |
Salacylic Acid | Topical Keratolytic agent Psoriasis Can cause skin irritation. |
Dithranol | Topical Anthralin Psoriasis Antimitotic effect reducing cell proliferation. 30 mins leave on time Staining and burning Dont use on face. |
Calcipotriol & Calcitriol & Tacalcitoil | Topical Vitamin D Analogue Psoriasis Inhibits cell proliferation and stimulates keratinocyte differentiation. Skin irritation. Avoid overdose due to hypercalcaemia. Tacalcitoil only on scalp and face. |
PUVA | Psoralen and UVA therapy. Psoralen soap or by mouth (2h before) Twice weekly. Wear glasses and keep covered up. Long term risk of epithelial cancers. Forms chemical bonds with DNA in the presence of UV radiation. Reduces cell proliferation. |
Methotrexate | Systemic cytotoxic immunosuppresant Folic acid antagonist. Immunosupression Bone marrow suppression. Teratogenic |
Azathioprine | Systemic cytotoxic immunosuppresant Psoriasis, Bullous disorder, Eczema Purine synthesis inhibitor. Inhibits proliferation of fast growing cells ie lymphocytes. Immunosupression. Test for GTPMT before prescribing Bone marrow suppression. Teratogen |
Hydroxycarbamide | Systemic cytotoxic immunosuppresant Enzyme inhibitor decreasing DNA replication. Polycythemia, Myeloproliferative, Sickle cell, psoriasis Immunosupression Bone marrow suppression. |
Infliximab | Biologic Monoclonal antibodies to TNF-alpha RA, Psoriasis, Crohns, Ulcerative Colitis |
Etanercept | Biologic Inhibits TNF-alpha RA, Psoriasis, Crohns, Ulcerative Colitis |
Adalimumab | Biologic Monoclonal antibodies to TNF-alpha RA, Psoriasis, Crohns, Ulcerative Colitis |
Efudex | Topical chemotherapy 5 fluorouracil Inhibits DNA synthesis and induces apoptosis Actinic keratosis and sometimes BCC |
Imiquimod | Topical immune response modification Unknown method of action Bowens, BCC, SCC, MM and AK |