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Mskeletal Physiology

Musculoskeletal Physiology for USMLE

QuestionAnswer
State the key cellular events in excitation-contraction coupling in skeletal muscle 1. APs cause depolarisation of T tubules 2. Ca2+ release from sarcoplasmic reticulum 3. Ca2+ binds troponin C 4. Tropomyosin moves to expose actin-binding site 5. Actin and myosin interact to generate contractile force 6. Ca2+ reuptake by SR
How does Ca2+ activate contraction in smooth muscle cells? By binding to calmodulin
Which muscle fibres are associated with peripherally located nuclei? Skeletal muscle fibres
Which muscle fibres are associated with centrally located nuclei? Smooth and cardiac muscle fibres
Which muscle fibres are associated with a distinct banding pattern? Cardiac and skeletal muscle fibres
Which muscle fibres are associated with the capacity to regenerate? Smooth muscle fibres
Which muscle fibres are associated with Z-lines? Cardiac and skeletal muscle fibres
Which muscle fibres are associated with gap junctions? Smooth muscle fibres
Which muscle fibres are associated with intercalated disks? Cardiac muscle fibres
Which muscle fibres are associated with synapses with perpheral nerves? Skeletal muscle fibres
Which muscle fibres are associated with inositol triphosphate (IP3)-mediated calcium release? Smooth muscle fibres
Which muscle fibres are associated with Ca2+ mediated calcium release? Cardiac muscle fibres
Which muscle fibres are associated with voltage-mediated T-tubule-mediated calcium release? Skeletal muscle fibres
Which muscle fibres are associated with troponin being the major calcium-binding protein? Cardiac and skeletal muscle fibres
What type of skeletal muscle fibre is associated with slow twitch? Type 1 ("one slow, fat, red ox")
What type of skeletal muscle fibre is associated with fast twitch? Type 2
What type of skeletal muscle fibre is associated with abundant lipid stores? Type 1
What type of skeletal muscle fibre is associated with red colour? Type 1
What type of skeletal muscle fibre is associated with white colour? Type 2
What type of skeletal muscle fibre is associated with primarily anaerobic metabolism and few mitochondria? Type 2
What type of skeletal muscle fibre is associated with primarily aerobic metabolism and many mitochondria? Type 1
What type of skeletal muscle fibre is associated with abundant glycogen stores? Type 2
What type of skeletal muscle fibre is associated with generation of a sustained force? Type 1
What type of skeletal muscle fibre is associated with generation of a sudden movement? Type 2
Created by: kuc