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WEEK 1:
Plenary:
| Question | Answer |
|---|---|
| symptom | physical/ mental feature indicating a disease that patient complains of |
| sign | indication of a disease detectable by medical practitioner even if patient not aware |
| symptoms of crohns disease | diarrhoea (+/- presence of blood), abdominal pain, weight loss, intestinal obstruction due to strictures, fistulae (often perianal), abscesses, good and bad days, systemic systems eg anorexia |
| signs of crohns disease | dehydration, anaemia, abdominal tenderness, weight loss, and during severe exacerbation/ sepsis - hypotension, tachycardia and pyrexia |
| what diagnostic test is used for patients with suspected severe IBD | AXR for initial assessment |
| calprotectin | small calcium binding protein |
| what to use when differentiating between IBD and IBS | calprotectin |
| how does calprotectin work in a positive test | concentration in faeces correlates well with severity of intestinal inflammation |
| normal faecal calprotectin predictive value for IBD | very high negative |
| investigations that can be used | endoscopy into ileum with biopsies, CT scan, MRI, ultrasound, and small bowel capsule |
| how are diagnosis confirmed | clinical evaluation and endoscopic, histological radiological, and biochemical investigations |
| when would a patient with crohn's be admitted to hospital | severe abdominal pain, severe diarrhoea (>8 times a day), patient is systemically unwell with a fever, evidence of bowel obstruction |
| treatment for crohns | IV fluids, analgesia, steroids, close monitoring, if complications eg bowel obstruction then consider surgery |
| long term management for crohn's | long term therapy as chronic disease |
| how is remission induced and maintained | induced by steroids and maintained by immunomodulators |
| complications of crohn's | strictures in bowel (leading to bowel obstruction), short bowel syndrome, malnutrition, osteoporosis, deficiencies (iron, B12, folate), and gallstones |
| therapeutic drug monitoring (TDM) as treatment for crohns | increase use of infliximab levels, adalimumab levels, anti drug antibodies |
| importance in nutrition in crohn's | iron deficiency management, vitamin B12 monitoring, vitamin D replacement, dietician involvement |
| example of malabsorptive condition | short bowel syndrome |
| short bowel syndrome | malabsorption disorder following removal of/ part of small bowel |