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WEEK 4:

embryology 4:

QuestionAnswer
what happens by 8th day of development blastocyst is partially embedded into endometrium
epiblast ectoderm
hypoblast endoderm
hypoblast layer consists of what type of cells small cuboid cells adjacent to blastocyst cavity
epiblast layer consists of what type of cells tall columnar cells on the trophoblastic side of the embryoblast
somatic mesoderm covers amniotic cavity and forms the amnion
splanchnic mesoderm lines trophoblast to form the chorion
rate at which cavities grow amniotic cavity enlarges faster than the chorionic cavity and gradually obliterates it and eventually the amnion and chorion join and the fetus floats in the amniotic fluid
changes in day 13 primitive yolk sac undergoes much reduction in size- where this reduced sac is lined by cells that migrate from hypoblast to form the secondary yolk sac and extraembryonic coelom transverses all of chorionic cavity except connectin stalk
umbilic cord is the connecting stalk
chorion is made of trophoblast and extra embryonic mesoderm
chorion eventually becomes smooth at abembryonic plate (chorion leave) and irregular (chorion frondosum) at the embryonic pole where placenta is developing
decidua modified endometrium of uterus during pregnancy
decidua basalis located at site of implantation between embryo and myometrium forming the maternal part of placenta
decidua capsularis thin layer that grows over embryo on luminal side enclosing it and connecting with decidua basalis
decidua parietalis lines rest of uterine cavity and is NOT in contact with embryo
decidua capsularis eventually fuses with what decidua parietalis
amniochorionic membrane made of amnion and chorion
importance of syncytiotrophoblast primary site of placental function eg nutrient and gas exchange, hormone production eg estrogen, progesterone and hCG
chorionic villi finger like processes on outer surface of chorion - in relation to decidua basalis, these grow extensively (chorion frondosum) contributing to formation of fetal part of placenta
primary villi trophoblastic cells form these
secondary villi mesodermal cells penetrate the core of the primary villi to form these
tertiary villi blood vessels develop in the mesoderm by end of third week forming these
when placental villi first form they are called primary stem cell villi which have a core of cytotrophoblast covered by a layer of syncytiotrophoblast
secondary villi have developed a core of extra embryonic mesoderm inside the 2 trophoblast layers
tertiary villi have developed what fetal blood vessels within the mesodermal core
stem/ anchoring villi extend where extend from chorionic plate to decidua basalis
free/ terminal villi are lateral branches of stem villi
FETO-MATERNAL barrier initially consists of 1. Syncytiotrophoblast 2. Cytotrophoblast 3. Mesoderm 4. Endothelium of fetal vessels (see tertiary stem villus cross section)
intervascular barrier tissue layers BETWEEN maternal and fetal bloods
first trimester few villi but large central few vessels (so exchange surfaces are small and distances large)
third trimester villi are numerous and small with peripheral fetal vessels (so exchange surfaces are large and distances small)
first trimester barrier comprises of layer of syncytiotrophoblast complete layer of cytotrophoblast substantial mesoderm endothelium of fetal vessels
third trimester barrier comprises of synctiotropholast layer isolated cytotrophoblast cells little mesoderm endothelium of fetal vessels
at 9 months, maternal blood enters cotyledons via 80-100 spiral aa
at 9 months, maternal blood leaves via tributaries of uterine vv
maternal (intervillous) blood space surrounds villous trees and holds about 150ml of blood
placental abruption/ abruptio placentae) placenta peels away from uterine wall partially or almost completely before delivery which can deprive fetus of oxygen and nutrients leading to poor growth and bleeding in mother or even premature births/ stillbirth (1/100 pregnancies)
placenta praevia low lying placenta covers part or all of opening of cervix which can block the baby's exit from uterus and blood vessels connecting abnormally placed placenta to uterus may tear leading to bleeding at labour and maybe premature birth (1/200 pregnancies)
placenta accreta placenta implants too deeply/ firmly into uterine wall (increta/perceta= embed into uterine muscle) which may cause excessive bleeding at delivery (1/2500 delivaries)
Created by: kablooey
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