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Neuro Drug Abuse-cas
Neuro
Question | Answer |
---|---|
CAGE | cutdown/control annoyed guilt about use eye opener (drink first thing in the morning) |
Acute symptoms of Niacin deficiency | Wernicke's--anterograde amnesia, |
Chronic symptoms of Niacin deficiency | Korsakoff's ---irreversible damages. these people have hole in hippocampus so they have persistent memory problems |
What do you do with alcoholics if they present at the ER | Do not give them IV glucose because they will further deplete their niacin/NADH and will aggravate their condition. Give them intramuscular thiamine |
Delerium Tremors | distinguished from dementia because this condition mental status waxes and wanes. The patient may hallucinate |
Idiosyncratic alcohol intoxication | some people become agitated a and uninhibited with |
Treating alcohol withdrawals | Barbituates (cross-reactive at GABA-R). Alcohol (tapering) can also be used Librium, Adavam, valium |
alcohol abuse prevention and sobriety | disulfaram (antabuse), naltrexone, AA |
Disulfaram | works on the acetyl-aldehyde dehydrogenase--> will cause nausea and vomiting when you drink because acetyl-aldehyde accumulates |
If you see a young athlete with psychotic symptoms what will be high on your differential? | anabolic steroid abuse |
Amphetamine Uses | Narcolepsy, ADD, Obesity (eg related drugs meridian, provigil) |
Commonality between all drugs of abuse (or chemicals, foods) | They all stimulate nucleus accumbens (may reinforce the behavior). The neurotransmitters at the end of this circuit are dopamine and opiates |
Welbutrin (buproprion) | one of few antidepressants that is not an SSRI; works by increasing NE/DA. It is used to treat people trying to quit smoking cigarettes |