Save
Upgrade to remove ads
Busy. Please wait.
Log in with Clever
or
show password
Forgot Password?
Don't have an account?  Sign up 
Sign up using Clever
or
Username is available taken
show password


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account. Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't Know
Remaining cards (0)
Know
0:00
edit
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

WEEK 9:

Intro to basic toxicology:

QuestionAnswer
what is a xenobiotic any foreign substance or exogenous chemicals to our body
classification of xenobiotics target organ classification according to use in public domain according to source according to effects according to physical state according to biochemical properties
most commonly reported poison analgesics
most commonly associated poisoning with most deaths analgesics
what poison is associated with least deaths hydrocarbons
common poisonous killer CO
what are analgesics medication used to relieve pain without causing loss of consciousness
quantal response is either response of no response (alive or dead) which is determined by distribution of responses to increasing doses in a population of test subjects or systems (all or none effect)
EC50 concentration of drug that gives half maximal response
IC50 concentration of an inhibitor where the response/ binding/ activity (proteins transporting) is reduced by half eg tofacinitib
tofacitinib selective inhibitor of an enzyme (Janus associated tyrosine kinases JAK1 and JAK3)
early measurement of IC50 values includes information on sensitivity of cell lines to cytotoxic drugs information of cell cycle information on rates of drug uptake, metabolism
clinical use of IC50 to determine selectivity among different tumour cell lines
ED50 median effective dose
TD50 median toxic dose
LD50 median lethal dose
TI therapeutic index ratio - margin of safety of a drug/ chemical substance
TI is measured using what ratio TD50:ED50
NOAEL no observable adverse effect level (highest exposure dose having no risks of toxicity)
hepatotoxicity drugs causing liver damage eg paracetamol poisoning/ overdose
nephrotoxicity drugs causing kidney damage in some patients eg NSAIDs jeopardise eGFR
Created by: kablooey
Popular Medical sets

 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
Retries:
restart all cards