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WEEK 23:

Breast cancer treatment:

QuestionAnswer
digital tomosynthesis multiple xrays of breasts in may angles creating a 3 dimensional picture of breasts
triple assessment (breast and axilla) history and examination, imagine, and tissue biopsy
surgery options in breast (3) breast conservation surgery, mastectomy, and reconstruction
surgery options in axilla (3) sentinel lymph node biopsy (if node negative), axillary node clearance (if node positive), and targeted axillary dissection (post neoadjuvant patients)
when is sentinel lymph node biopsy done in axilla when node is negative
when is axillary node clearance done in axilla when node positive
radiotherapy types (2) external beam RT (most commonly used) and brachytherapy
first line endocrine treatment SERM ( Selective Estrogen Receptor Modulator) Tamoxifen,Raloxifene Aromatase inhibitors Letrozole,Anastrozole,Exemestane CDK4/6 inhibitors Palbociclib,ribociclib,Abemaciclib
second line endocrine treatment PI3K/AKTmTOR pathway down regulator Everolimus CDK4/6 inhibitors Palbociclib,ribociclib,Abemaciclib
targeted therapy (2) anti HER2 treatment and bone modifying agents
anti HER2 treatment as a targeted therapy Trastuzumab ( Herceptin) Pertuzumab Pertuzumab,Trastuzumab and Hyaluronidase ( PHESGO) Trastuzumab-Emtansine ( Kadcyla) Tyrosine kinase inhibitors Lapatinib, Neratinib
bone modifying agents as a targeted therapy Bisphosphonates ( inhibit osteoclasts): Clodronate, Ibandronate, Zolendronic acid Denosumab: Osteoclast-targeted therapy called a RANK ligand inhibitor
gynaecomastia male breast cancer that can be unilateral/ bilateral and presents as enlargement/ defined mass. Marker of hyperostrogenism and neoplasm needs to be excluded
Created by: kablooey
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