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WEEK 22:

Lung cancer treatment and prognosis:

QuestionAnswer
predictors of survival (3) tumour related factors (eg stage of disease, tumour size and location), patient related factors (etc age, smoking), and treatment related factors (eg treatment adherence or access to care)
types of treatment (2) curative and palliative
curative treatment (3) surgery, radical radiotherapy (including stereotactic ablative radiotherapy SABR), and radical chemotherapy
classification of LC (3) SCLC, NSCLC (lung adenocarcinoma, squamous cell carcinoma, and large cell carcinoma), and pulmonary carcinoid tumours
palliative treatment (3) radiotherapy, systemic anticancer treatment, and combinations
modalities of treatment (4) radiotherapy, chemotherapy, chemo-radio, and surgery
adenocarcinoma mutations in EGFR
squamous cell carcinoma associated withTP53
induction chemotherapy
neo-adjuvant chemotherapy
adjuvant chemotherapy post op to reduce chance of metastasis
adjuvant immunotherapy
targeted treatment drugs designed to attack specific genetic mutations (driver mutations) to kill cancer cells and spare healthy cells
how is cancer treatment chosen based on cancer type (NSCLC etc), stage, molecular profile (etc EGFR), and patient factor (etc age, comorbidities and preferences)
NSCLC treatment** high prevalence of targetable mutations where stage storngly determines surgery etc
SCLC treatment
carcinoid tumours treatment
monoclonal antibodies
treatment for no driver mutation cancer tumours** immunotherapy +/- chemotherapy when PDL1..
immune checkpoint inhibitors
role of PD1** bind to PDL1 on the lung cancer cell become 'exhausted' and inhibits growth
SABR (stereotactic ablative body radiotherapy) or stereotactic body radiotherapy SBT
No fly zone - complications massive haemoptysis, penumonia, airway necrosis, and pericardial effusion
RATS (robotic assisted thoracic surgery)
follow up care crucial in monitoring patients recovering and detecting recurrence, managing side effects of treatment and improving long term outcomes
Created by: kablooey
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