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WEEK 20:
Cardiac Function:
| Question | Answer |
|---|---|
| formula for cardiac output | cardiac output (L/min) = stroke volume (L/beat) x heart rate (bpm) |
| cardiac output at rest | 5L/min = 70mL/beat x 70bpm |
| cardiac output during exercise | 22L/min = 110ml/beat x 200bpm |
| cardiac output depends on (2) | factors affecting heart rate and factors affecting stroke volume |
| how to measure heart rate (3) | pulse oximeter, counting pulses in major arteries (radial, brachial, femoral), and analysis of ECG |
| pulse oximeter | measures automatically beat by beat but can be affected by physical factors eg cold peripheries and does not show character of pulse or regularity/ irregularity |
| peripheral pulses | count number of pulses in 60 secs which allows you to estimate character of pulse and regularity/ irregularity |
| normal heart rate range | 60-100bpm |
| ECG as a mean of measuring heart rate | often detect most common arrhythmias, count number of QRS complexes/R waves in 10secs (so x6 to get HR) |
| heart rate influenced by (4) | SNS, PNS, hormones and extra/intracellular ions (alter membrane potential) |
| factors affecting heart rate | intrinsic rate (SAN and AVN conduction) |
| stroke volume determined by interaction of (3) | preload (volume of blood in ventricles before systole), cardiac contractility (how efficient myocardium is at contracting), and after load (pressure needed for ventricles to contract and open valves) |
| stroke volume | difference between end diastole volume (EDV) and end systolic volume (ESV) |
| slide 8** factors affecting stroke volume** | posture, intrathoracic pressure (breathing in/out), filling time, atrial contractility |
| Frank Starling Curve | force of contraction of cardiac muscle fibres is proportional to degree of stretch (increased stretch EDV means increased force of contraction therefore increased contractility) |
| cardiac contractility and stroke volume increases and depends on | amount of force generated by cardiac muscles which depends on degree of stretch (eg increases if SNS activity increases) |
| cardiac contractility and stroke volume decreases and depends on | hypoxia, acidosis, heart failure, and reduced SNS |
| increased aortic pressure means | increased afterload (pressure needed to contract ventricle) increases which will reduce stroke volume at constant preload |
| velocity of ventricular contraction at fixed length is greatest when | afterload is low (as needs less pressure and therefore effort to contract) |
| slide 13-16 relationship between stroke volume, pressure and volume graph** | LV pressure mmHg on Y axis and LV volume ml on X axis |
| explain the stroke volume graph** | |
| increased EDV (preload)/ increased cardiac contractility leads to | increased stroke volume |
| increased aortic pressure (afterload) leads to | decrease in stroke volume |