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WEEK 18:

Reintroduction to pharmacokinetics:

QuestionAnswer
Vd formula dose/ t0 conc
CL general formula rate of elimination (kidney/liver/other) / C
first order kinetic formula Ct = C0e^-kt
e value 2.718
k = CL/ Vd
t1/2= 0.693 (loge 2) / k
describe steady state (Css) administration rate = delimination rate
aminophylline IV loading dose for severe acute asthma in adults 250-500mg IV injection
what is the loading dose of aminophylline followed by in severe acute asthma in adults maintenance dose
infusion rate/ elimination rate = clearance x Css
exponential decay graph 1st order graph (conc against time) with distribution and elimination phase
k fraction eliminated per unit time
Ct conc at t=t
C0 conc at t=0
short t1/2 means more frequency
long t1/2 means less frequency
loge 2 value 0.693
how does infusion rate affect Css (steady state) higher infusion rate means higher Css (eg faster tap means higher water level)
time to steady state depends on what drugs half life
how many half lives are needed to reach steady state 5
loading dose initial infusion of drug to get drug concentration into therapeutic window (0 order)
maintenance dose given after loading dose to maintain steady state concentration in therapeutic window (Css)
elimination first order, depending on concentration
difference between clearance and elimination elimination is how much drug is removed by clearance is how efficiently drug is removed
amount = salt x dose
salt factor proportion of drug which is active
clearance definition volume of plasma completely cleared of drug per unit time
Created by: kablooey
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