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WEEK 7:
T Cell mediated immunity:
| Question | Answer |
|---|---|
| how do B cells recognise antigens/pathogens | in their native form (direct recognition) using B cell receptors on cell surface |
| how do T cells recognise antigens/pathogens | not in their native form (indirect recognition) where the pathogen must be processed/ presented on major histocompatibility complex (MHC) class I or class II |
| what do B cells present on their cell surface that acts as antigen receptors | immunoglobulins |
| structure of B cell immunoglobulin receptors | 2 heavy and 2 light chains |
| what are the domains of a B cell immunoglobulin receptors | constant (C) and variable (V) domains |
| describe antigen binding sites on B cell immunoglobulin receptors | 2 identical antigen binding sites each composing of variable domains (1 heavy and 1 light chain) |
| describe antigen binding sites on T cell receptors | made of two chains (alpha and beta) with constant and variable domains |
| types of T cells | CD4 and CD8 |
| CD4 helper T cells | |
| CD8 cytotoxic T cells |