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Compounding/Hazard

Compounding with Hazardous Drugs

TermDefinition
Background Information Regarding Hazardous Drugs 1. HDs can cause toxicity to workers who handle them 2. Equipment, devices, and environments are designed to reduce exposure 3. Standards are set by USP 800
Select Hazardous Key Drugs on the NIOSH List Antineoplastics, 5-alpha reductase inhibitors, abortifacients, warfarin, transplant meds, clonazepam, temazepam, hormonal agents, ASMs, paroxetine, tretinoin, thionamides, PAH medications, tx for autoimmune conditions, spironolactone, valganciclovir
Biological safety cabinets (BSCs) BSCs have unidirectional airflow, where air moves vertically from the top of the hood
Negative Air Pressure C-PECs, C-SECs, and C-SCAs require negative air pressure so that air flows into the rooms, avoiding spreading potentially toxic particles into the pharmacy
Caveats to Hazardous Compounding Garbing/Processing Two pairs of appropriate gloves must be worn, two pairs of shoe covers are required, gown MUST be disposable, eye/face protection, respirator (N95), pneumatic tubes can't be used for liquid HDs and antineoplastics, don't inject air in vial
Created by: skelly46
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