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Compounding/Hazard

Nonsterile Compounding

TermDefinition
Surfactant Lowers the surface tension between two ingredients to make them more miscible
Wetting agents/levigating agents Reduce the surface tension between a liquid and a solid
Suspending agents Added to a suspension to keep the solid particles from settling
Emulsifiers Added to emulsions (two or more immiscible liquids) to help keep the liquid droplets dispersed throughout the liquid vehicle
The Hydrophilic-Lipophilic Balance HLB ranges from 0-20. HLB < 10 = more lipid-soluble. HLB > 10 = more water-soluble
Binders Allow the contents of a tablet to stick together while permitting release once ingested
Preservatives Prevent microorganism growth
Buffers Keep pH within a certain range
Emollients Products that soften and smooth the skin. Ointments are for extremely dry skin & thick skin Creams are usually best fit for normal and dry skin Lotions have the most water and are best for oily skin
Excipients to avoid in some patients Alcohol: Children Aspartame: Phenylketonuria Gelatin: Anyone whishing to avoid animal products Gluten: Celiac disease Lactose: Lactose allergy/intolerance Preservatives: neonates Sorbitol: IBS Sucrose: Diabetes Xylitol: Dogs; humans w/ GI upset
BUDs for Nonsterile Compounded Products Nonpreserved aqueous dosage forms = 14 days (fridge) Preserved aqueous dosage forms = 35 days Nonaqueous oral liquids = 90 days Other nonaqueous dosage forms = 180 days
Created by: skelly46
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