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Key Drugs & Facts 1

KDF - Pharmacy Foundations 1

TermDefinition
Pharmacodynamics Refers to the effect the drug has on the body
Pharmacokinetics Refers to the effect or change the body has on the drug
Principles of Pharmacokinetics Absorption, Distribution, Metabolism, Excretion
Common Prodrugs & Active Metabolites Capecitabine to 5-FU Clopidogrel to active metabolite Codeine to morphine Fosphenytoin to phenytoin Levodopa to dopamine Lisdexamfetamine to dextroamphetamine Prednisone to prednisolone Primidone to phenobarbital Valacyvlovir to acyvlovir
Clopidogrel Drug Interaction Risk with 2C19 inhibitors, including omeprazole and esomeprazole
Common CYP Inhibitors - G ♥ PACMAN Grapefruit ♥ Protease Inhibitors (ritonavir) Azole antifungals Cyclosporine, cobicistat Macrolides (NOT azithromycin) Amiodarone (and dronedarone) Non-DHP CCBs (diltiazem and verapamil)
Common CYP Inducers - PS PORCS Phenytoin Smoking Phenobarbital Oxcarbazepine Rifampin (and rifabutin, rifapentine) Carbamazepine St. John's Wort
Statin Drug Interaction Simvastatin & lovastatin CI'd with strong CYP3A4 inhibitors
References by Topic USP 795 - Non-sterile preparations USP 797 - Sterile preparations USP 800 - Hazardous Drugs Red Book - Drug Pricing Orange Book - Therapeutic Equivalents Purple Book - Biologic Interchangeability Pink Book - Vaccine- Preventable Diseases
References by Topic Pt 2 Yellow Book - International Travel MedWatch - AE Reporting ISMP - Med Error Reporting NatMed - Natural Medicines Brigg's, Hale's - Pregnancy & Lactation Green Book - Animal Drug products
Patch Frequency BID - Diclofenac QD - Methylphenidate, nicotine, rivastigmine, selegiline, testosterone (lidocaine & NTG 12 on/off) Q72 - Fentanyl, scopolamine Twice Weekly - Estradiol, oxybutynin Weekly - Donepezil, buprenorphine, clonidine
Drugs That Require Non-PVC Containers (Leach Absorbs to Take in Nutrients) Lorazepam Amiodarone Tacrolimus Taxanes Insulin Nitroglycerin
Drugs to Mix in Saline Only (A DIAbetic Can't Eat Pie) Ampicillin Daptomycin Infliximab Amp/sulbactam Caspofungin Ertapenem Phenytoin
Drugs to Mix in Dextrose Only (Only Sugar Always) Oxaliplatin SMX/TMP Amphotericin B
Common Drugs With Filter Requirements (my GAL IS PAT who has a MAP) Golimumab Amphotericin B Lipids - 1.2 micron Isavuconazonium Phenytoin Amiodarone Taxanes Mannitol > 20% Parenteral nutrition > 1.2 micron
Drugs That Shouldn't Be Refrigerated (Dear Sweet Papa, Fucking Makes Me Edge) Dexmedetomidine SMX/TMP Phenytoin Furosemide Metronidazole Moxifloxacin Enoxaparin
Created by: skelly46
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