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Herpesvírusok

Ebstein-Barr, gamma

TermDefinition
terjedés módja nyál (csók-betegség felnőttbe)
jellemzői (2) -gazdaspec. -II.-es komplement rec-cel rendelkező sejtet fertőz (B sejt, oropharynx epithelsejt, MHCII)
pathogenesis nyál->oropharynx->tonsillák->B-sejt
kimenete (3) -B sejtbe permisszíven szaporodik, látens lesz, újra aktiválódhat -kiszabadul sejtysist okozva -T-sejtek kordában tartják
lefolyása (2) -B-sejt heterophillAT-et képez, prezentálja T-nek -T Downey-sejt=autoreaktív T sejt a B ellen
következmény (2) -splenomegalia (B-T túltermelés miatt) -lymphadenopathia -
incubatios idő 2 hónap
betegségek -Alice in wonderland sy -Kikuchi-betegség -szőrős leukoplakia -lymphoprolif betegség -nasopharyngealis cc -Burkitt- lymp -heterophil AT pos. mononuclearis infectiosa -exsudativ pharyngitis -1 hónapig tarthat -fejfájás
gyerekbe tünetmentes
komplikációk -krónikus EBV-hepatitis, pneumonia -GB sy -gége ödéma -lép ruptura
diagnosis -fhv 60-70% mononuclearis -B-sejt heterophil IgM AT--> Paul-Bunnell
Paul-Bunnell próba mosottt erhytrocyta + mononucl. beteg minta ha van agglutináció +birka, lóból
terápia aktív vírus ellen: Aciclovir (látensre nem hat)
Created by: Farmakodinámia
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