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Transplant 2

Surgery 2

QuestionAnswer
a molecule that can interact with the immune system antigen
peptides produced by B lymphocytes that attach to foreign material and aid in removing it from the body antibody
cells that display foreign antigen complexed with MHC on its surface. antigen presenting cell
these genes are expressed on the surface of cells in all jawed vertebrates, and display fragments of molecules from invading microbes or dysfunctional cells major histocompatibility complex MHC
are encoded by the MHC genes Human Leukocyte Antigens HLA
circulation peptides that influence behavior of the immune system (IL-2) cytokines
a protein complex of T lymphocytes that can identify MHC molecules T-Cell Receptor
interact with APC MHC II molecules via the TCR release cytokines (primarily IL-2) CD4 lymphocyte
interact with MHC class I molcules (that contain foreign peptides) and can directly kill the foreign cell CD8 T lymphocyte
of the same species allogenic
a test for determining tissue compatibility between a transplant donor and the recipient before transplantation, in which the recipient's serum is tested for antibodies that may react with the lymphocytes or other cells of the donor crossmatch
the preexisting antibodies against HLA antigens in the serum of a potential allograft recipient that reacts with a specific antigen in a panel of leukocytes, with a higher percentage indicating a higher risk of a positive crossmatch (listed as % antib) panel reactive antibodies PRA
a state of immune acceptance without immunosuppression tolerance
MHC I goes with __ CD8 T cells (8/1=8)
MHC II goes with __ CD4 T cells (8/2=4)
what are the 2 allogenic recognition pathways direct and indirect
T-cells and their receptors identify allogeneic MHC molecules. This generates CD8 T cells which causes attack on an organ and therefore rejection direct allogenic recognition pathway
antilymphocyte antibodies used to prevent rejection until maintenance suppression is therapeutic induction immunosuppression
the important cytokine to remember from the transplant lecture IL-2
drugs that end in "-mab" are __ monoclonal antibodies
when a transplanted organ is placed in its normal anatomic location in the recipient orthograft
when a transplanted organ is placed in an area that is not its normal anatomic location in the recipient heterograft
major cause of increased demand for organs hepatitis C
antigen presenting cell APC a cell that displays foreign antigen complesed with MHC on its surface, which is then recognized by t-cell receptors on T cells
major histocompatibility complex MHC genes expressed on the surface of cells in all jawed vertebrates and display fragments of foreign molecules to T cells
define cross match a test for determining tissue compatibility between a transplant donor and the recipient before transplantation, in which the recipient's serum is tested for antibodies that may react with the lymphocytes or other cells of the donor
which cytokine is responsible for the majority of immune cell activation interleukin 2 IL-2
immediate killing of a transplanted organ occuring in patients with preformed antibodies to the donor in the bloodstream hyperacute rejection
rejection of the transplanted organ occurring between 5-90 days due to the infiltration of the recipient's immune system into the donor organ acute rejection
chronic allograft vasculopathy due to development of atherosclerosis chronic rejection
antilymphocyte antibodies used to prevent rejection during first few days after TP induction immunosuppression
maintenance immunosuppression long term therapy with two or three drugs
treatment of acute rejection steroids and antilymphocyte preparations given over period of several days
most important side effect of cyclosporine nephrotoxicity
most important complication of immunosuppression opportunistic infection
how are donor organs transported hypothermic storage with UW solution
why is the left kidney preferred in renal transplant the renal vein is longer on the left side
what lab value is used to evaluate success of liver transplant PT/INR
what lab value is used to evaluat the success of pancreatic transplant glucose
1-year survival rate following liver transplant 85%
1-year survival rate following heart transplant 80%
1-year survival rate following lung transplant 70%
what imaging modality is used to evaluate liver and kidney anastomoses post-operatively ultrasound
what consideration must be made regarding pancreas transplant risk of diabetic complications vs complications of lifelong immunosuppression therapy
what clinical sign is associated with acute heart transplant rejection tachycardia
approach to the patient 3 hours post renal transplant who stops making urine flush foley cath, assess fluid status(give 500cc crystalloid LR or NS), ultrasound to assess renal artery/vein patency, return to OR
why must you be overly concerned for infectious processes in patients s/p organ transplant immunosuppression therapy results in a blunted inflammatory response and thus, the patient will no present with typical symptoms
fever threshold in immunocompetent 38.5 C
fever threshold in immunocompromised 38.0 C
what are patients s/p lung transplant at greatest risk for infection secondary to aspiration
Created by: Abarnard