Save
Busy. Please wait.
Log in using Clever
or

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever
or

Username is available taken
show password

why


Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.


Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
focusNode
Didn't know it?
click below
 
Knew it?
click below
Don't know
Remaining cards (0)
Know
0:00
share
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Wound Healing 1

Surgery 2

QuestionAnswer
Biggest determining factor of whether wound will heal: blood supply
Phases of Wound Healing: Hemostasis, plt plug / fibrin clot formation; inflam & recruitment; fibroblast proliferation & granulation; maturation (wound remodeling & contraction)
Order of arrival of cells to newly injured tissue Platelets; neutrophils; monocytes/ macrophages; fibroblasts
Fn of Platelets: plug any bleeding defects to form a clot, which provides a fibrous framework for later events.
Cells that stimulate mast cells to release histamine: Platelets and leukocytes
Fn of Neutrophils: phagocytosis of debris & release of cytokines to recruit other cells; die within 24-48 hrs; release lysosomal enzymes, which digest necrotic debris
Fn of Monocytes/macrophages arrive at approx. same time as neutrophils, but live longer and predominate after 3rd day
Fn of Fibroblasts appear at about 24 hrs; attach to fibrin scaffolding deposited in wound during initial clotting.
Predominant cells in a normal wound at 10 days: Fibroblasts
Reasons for difficult healing in Diabetes: Impaired microvasculature, impaired inflammatory response
Reasons for difficult healing in Glucocorticoids: Immunosuppression, reduced tensile strength
Reasons for difficult healing in Radiation and Chemotherapy: Arteriolar and fibroblast damage, BM suppression
Treatment for an abscess is: Drainage
Primary closure: prompt suture closure after irrigation; heals the most rapidly w/ the best scar; can be used in clean & clean-contaminated wounds; also clean, fresh traumatic lacerations.
Secondary intention: wound is left open & allowed to granulate in; generally involves debridement, irrigation, & frequent dressing changes
Delayed primary closure: wound is cleaned, debrided, irrigated, & closed 3 to 5 days later
Cofactors required for collagen synthesis Vitamins C&E; Iron; Oxygen; Protein; Galactose; Glucose; Manganese
Wound: Clean: non-traumatic, uninfected, incision under aseptic conditions as in the OR; e.g. median sternotomy incision, hernia; infection rate < 5%
Wound: Clean-contaminated: normal flora, wounds involving oral cavity, respiratory, upper alimentary, or GU surgery; e.g. esophageal, cholecystectomy, colectomy; infection rate < 10%
Wound: Contaminated: fresh traumatic lacerations, operative procedures with gross soilage; ex: colostomy, bowel resection w/ enterotomy; acute cholecystitis w/ pus; infection rate < 15%
Wound: Dirty/Infected: heavily contaminated wounds, traumatic wounds greater than 6 hours old, grossly infected wounds; ex: pelvic abscess, gangrene of extremity, perf viscus, perirectal abscess, leg ulcer; infection rate 30%
Factors that Influence Healing: Infection/ contam; Nutrition; DM; Jaundice; Uremia; Steroids; CT/radiation; Hypoxia (smoking); edema
Created by: Abarnard
 

 



Voices

Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!

"Know" box contains:
Time elapsed:
Retries:
restart all cards