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Drug quiz 2
Generic | Brand | Selected Adverse Effects | PHARMACY CATEGORY | Consideration |
---|---|---|---|---|
Buprenorphine | Buprenex | 1. Respiratory depression 2. Dizziness 3. Sedation | Analgesic, Opioid | ISMP High-alert medication |
Fentanyl | Sublimaze | 1. Constipation 2. Confusiondizziness 3. Respiratory depression | Analgesic, Opioid | ISMP High-alert medication |
Hydromorphone | Dilaudid | 1. Constipation 2. Flushing 3. Hypotension 4. Itching 5. Respiratory depression | Analgesic, Opioid | ISMP High-alert medication |
Ketorolac | Toradol | 1. Dyspepsia 2. GI symptoms (nausea, abdominal pain, constipation, diarrhea) 3. GI bleeding (rare but serious) | NSAIDS | |
Morphine | Duramorph, Infumorph | 1. Constipation 2. Drowsiness 3. Nausea/ vomiting 4. Respiratory depression | Analgesic, Opioid | ISMP High-alert medication Use only preservative-free solutions for epidural administration |
Ketamine | Ketalar | 1. Prolonged emergence from anesthesia (confusion, delirium, dreamlike state, hallucinations, vivid imagery) | Antidepressant; General Anesthetic | ISMP High-alert medication |
Lidocaine | Xylocaine | 1. Dizziness 2. Nausea vomiting 3. Paresthesia 4. Hypotension | Antiarrhythmic Agent, Class Ib; Local Anesthetic | ISMP High-alert medication |
Propofol | Diprivan | 1. Apnea 2. Hypotension 3. Injection site pain 4. Hypertriglyceridemia | General Anesthetic | ISMP High-alert medication Expires 12 hours from opening. All tubing and unused portions should be discarded at that time. |
Fosphenytoin | Cerebyx | 1. Ataxia 2. Nystagmus 3. Somnolence | Antiseizure Agent, Hydantoin | Rate infusion:not faster than 150 mg PE/ minute |
Levetiracetam | Keppra | 1. Hypertension 2. Vomiting 3. Somnolence | Antiseizure Agent, Miscellaneous | |
Phenytoin | Dilantin | 1. Exfoliate dermatitis 2. Stevens-Johnson syndrome 3. Blood dyscrasias 4. CNS toxicity | Antiseizure Agent, Hydantoin | Rate of infusion: do not infuse faster than 50 mg/minute |
Valproate | Depacon | 1. Thrombocytopenia 2. Tremor 3. Diplopia | Antimanic Agent; Antiseizure Agent, Miscellaneous; Histone Deacetylase Inhibitor | |
Haloperidol lactate | Haldol | 1. Extrapyramidal reactions 2. Hyperkinesia 3. Akathisia | First Generation (Typical) Antipsychotic | Note salt formulation: haloperidol lactate can be administered IM or IV; haloperidol decanoate is a long-acting formulation and is only for IM injection - should never be given IV. |
Olanzapine | Zyprexa | 1. Drowsiness 2. Extrapyramidal symptoms | Antimanic Agent; Second Generation (Atypical) Antipsychotic | |
Ziprasidone | Geodon | 1. Drowsiness 2. Extrapyramidal symptoms | Antimanic Agent; Second Generation (Atypical) Antipsychotic | |
Diazepam | Valium | 1. Drowsiness 2. Slow breathing rate | Benzodiazepine | |
Lorazepam | Ativan | 1. Drowsiness 2. Slow breathing rate | Benzodiazepine | ISMP High-alert medication |
Midazolam | Versed | 1. Drowsiness 2. Slow breathing rate 3. Decreased tidal volume | Benzodiazepine | ISMP High-alert medication Some formulations contain benzyl alcohol; use a preservative-free injection formulation in neonates |
Acetylcysteine | Acetadote | 1. Anaphylaxis | Antidote; Mucolytic Agent | Should be administered through an in-line filter |
Atropine | Atropine | 1. Anticholinergic side effects (dry mucous membranes, urinary retention) 2. Tachycardia | Anticholinergic Agent, Ophthalmic; Ophthalmic Agent, Mydriatic | |
Flumazenil | Romazicon | 1. Vomiting 2. Tremor 3. Ataxia | Antidote | May precipitate seizures in patients who have been on long-term benzodiazepine therapy |
Leucovorin | 1. GI side effects (nausea/vomiting/diarrhea) 2. Fatigue | Antidote | ||
Naloxone | Narcan | 1. Dizziness 2. Flushing 3. Injection site reactions 4. Nausea/vomiting | Antidote; Opioid Antagonist | Because naloxone has a short half-life, it may need to be administered multiple times until opioid wears off |
Octreotide | Sandostatin | 1. Abdominal pain, diarrhea, flatulence, 2. Hyperglycemia | Antidiarrheal; Antidote; Somatostatin Analog | |
Zoledronic acid | Reclast; Zometa | 1. Bone pain 2. Arthralgia 3. Hypotension | Bisphosphonate Derivative | Administer through a separate IV line. Do not mix with any calcium or divalent cation containing solutions. |
Dexamethasone | Decadron | 1. Fluid retention 2. Fragile skin 3. Hyperglycemia 4. Hypertension 5. Mood changes | Anti-inflammatory Agent; Antiemetic; Corticosteroid, | |
Hydrocortisone | Solu-Cortef | 1. Fluid retention 2. Fragile skin 3. Hyperglycemia 4. Hypertension 5. Mood changes | Corticosteroid | |
Methylprednisolone sodium succinate | Solu-Medrol | 1. Fluid retention 2. Fragile skin 3. Hyperglycemia 4. Hypertension 5. Mood changes | Corticosteroid | |
Diphenhydramine | Benadryl | 1. Sedation 2. Anticholinergic effects (e.g., urinary retention, dry mouth) | Histamine H1 Antagonist, First Generation | Diphenhydramine injection can cause local skin necrosis and should never be given subcutaneous or intradermal. For IM injections, make sure they are given deep IM. |
Promethazine | Phenergan | 1. Bradycardia 2. Sedation 3. Phlebitis | Histamine H1 Antagonist, First Generation | ISMP High-alert medication Vesicant, can cause severe tissue damage/necrosis. Should not be administered IM or IV push. Should be diluted and administered slowly as an IV intermittent infusion or via a central line to avoid extravasation. |
Ranitidine | Zantac | 1. Constipation 2.Diarrhea 3. Nausea | Histamine H2 Antagonist | |
Ondansetron | Zofran | 1. Constipation 2. Diarrhea 3. Headache | Selective 5-HT3 Receptor Antagonist | |
Pantoprazole | Protonix | 1. Constipation 2. Diarrhea 3. Headache | PPI | |
Infliximab | Remicade | 1. Infusion-related reactions (e.g., chills, fever, rigors, myalgias, headache, cough) 2. Upper respiratory tract infection | Immunosuppressant Agent, TNF-alpha | ISMP High-alert medication Short-stability medication - use within 3 h and use in-line ≤1.2 micron low protein binding filter. not infuse or mix with other solutions . May require premedications prior to infusion to decrease infusion-related reactions. |
Rituximab | Rituxan | 1. Infusion-related reactions (e.g., chills, fever, rigors, myalgias, headache, cough) 2. Fatigue | Immunosuppressant Agent; Monoclonal Antibody | ISMP High-alert medication Patients should be premedicated prior to infusion and infusions should be titrated upwards to decrease infusion-related reactions. |
Oxytocin | Pitocin | 1. Headache 2. Nausea, vomiting | Oxytocic Agent | ISMP High-alert medication NIOSH recommends using double gloves and wearing protective gown when preparing solutions. Many institutions develop an oxytocin infusion protocol in order to improve maternalfetal safety and reduce medication errors. |