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Pharmacology Med.
Anticoagulants/Platelets Inhibitors/Thrombolytic & Diuretec Drugs-kidney functio
| Question | Answer |
|---|---|
| Brand Name Coumadin | Generic Name warfarin sodium |
| Coumadin/Warfarin | Oral anticoagulation therapy. Blocks intrinsic pathway. Inhibity syntesis of Vit K. Prevents growth of formed clots. |
| Brand Name Heparin | Generic Name heparin |
| Heparin | Injectable anticoagulation therapy. Works immediately. Inhibits clots by blocking fiber production. |
| Brand Name Reopro | Generic Name abciximab |
| Reopre/abciximab | Biologic - few side effects. adjucnt to heparin. |
| -ab | Monoclonal antibody fragment works on platelets only |
| Brand Name Activase I.V. | Generic Name alteplase |
| Activase I.V/alteplase | Biologic. Single dose clot buster |
| -ase | enzyme |
| Brand Name Procrit | Generic Name epoetin alpha |
| Procrit means | Promote red blood cell production |
| Procrit/epoetin alpha | Hormone and also a biologic. Stimulates red blood cell production for anemia, cancer, chronic renal failure |
| Blood Clots | Thrombus |
| thrombus | stationary clot |
| embolus | circulating clot |
| thromboembolization | movement of clot |
| statis | stops blood and it pools in atrium. |
| atrial fibulation | quivering of atrial valve. irregular rhythm. |
| Intrinsic pathway | blood coming in contact with foreign object. cut on glass etc. |
| Extrinsic pathway | internal issue. |
| How clots form | RBC's get trapped in fiber structure and starts forming clots. Platelets which are smaller than RBC's stablalize the clots. |
| -mab | monoclonal antibody |
| -ase | enzyme |
| -lysis | break apart |
| fibrinolysis | breaks apart fiber |
| small molecule drugs | older, cheaper priced. synthasized by chemical reactions |
| large molecule drugs | Biologics - ex. vaccine. Proteins - synthasized by biological systems ex. cells. More expensive priced. Hard to reproduce generic. Much more complex. |
| Diuretics | increase urine production. Increase water loss. Used for edema and conjestive heart failure. |
| Furosemide | Loop diurectics. used in Loop of Henle. High capacity. |
| Thiazides | used in distal convoluted tubule |
| Spironolacton | potassium sparing diuretic used in collecting tubule |
| Nephron | structual unit of kidney. complex filter. |
| glomerulus | leaks out liquids (salts etc.) |
| Kidney does what? | recycles |
| How many different tubules in kidney? Name? | 5. Proximal convoluted tubule, Proximal straight tubule, Loop of Henle, Distal convoluted tubule, Collecting tubule. |
| Diuretic drug brand name Diaqua | Generic name hydrochlorothiazide HCTZ |
| -iazide | suffix for generic thiazide diuretics. they act on distal convoluted tubule. |
| Diuretic drugs treat what? | edema and hypertension |
| Diuretic drug brand name Lasix | generic name furosemide. Works in Loop of Henle. |
| Diuretic drug brand name Aldactone | generic name spironolactone. Works in collecting tubule. Potassium sparing diuretic. |
| Diuretic drug brand name Dyazide | generic name HCTZ/triamterene |
| Dyazide - HCTZ/triamterene | combination diuretic drug of Diaqua and Aldactone |
Created by:
kjlange
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