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Give 5 Major Categorical causes of thrombocytopenia 1 Spurious, 2 Decreased Production, 3 Increased Destruction, 4 Dilutional, 5 Sequestration (Hypersplenism).
Thrombocytopenia - Conditions of Decreased production: Aplastic anemia: congenital and acquired, Marrow infiltration: leukemia, disseminated cancer, Drug-induced: alcohol, thiazides, cytotoxic drugs, Infections: measles, HIV. Ineffective megakaryopoiesis: Megaloblastic anemia & Myelodysplastic syndromes
Thrombocytopenia - Conditions of Decreased platelet survival (Increased destruction) - Immunologic destruction: idiopathic thrombocytopenic purpura, systemic lupus erythematosus, post-transfusion and neonatal. Drug-associated: quinidine, heparin (HIT), sulfa compounds. Infections: infectious mononucleosis, HIV infection, cytomegalovirus.
Thrombocytopenia - Conditions of Decreased platelet survival (Increased destruction)- Non-immunologic destruction: Disseminated intravascular coagulation, Thrombotic thrombocytopenic purpura TTP, Giant hemangiomas, Microangiopathic hemolytic anemias
Thrombocytopenia - Drugs which cause decreased production: Alcohol, thiazides, cytotoxic drugs.
Thrombocytopenia - Drugs which cause increased destruction: quinidine, heparin, sulfa compounds
Created by: graziant