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Diseases of pancreas

MEDOP 230- Endocrinology: Diseases of the pancreas

DiseaseDefinitionNoteSymptom
Hyperinsulinism Condition in which a pancreatic adenoma causes hypersecretion of insulin. • High insulin levels lead to low blood glucose (hypoglycemia). • If untreated, hypoglycemia can progress to insulin shock and coma. • Symptoms of hypoglycemia include shakiness, headache, sweating, dizziness, and fainting.
Insulin resistance syndrome (IRS) Condition in which hypersecretion of insulin occurs because cell receptors develop resistance to insulin. • Receptor resistance- glucose remains in blood instead of entering body cells. • The pancreas senses high glucose level and tries to lower it by secreting more insulin. • Eventually, the pancreas becomes exhausted and the patient develops DM
Diabetes mellitus (DM) hunger). Condition in which the beta cells of the pancreas are unable to secrete enough insulin.
hyperglycemia Low insulin levels result in elevated blood glucose
Glycosuria excess glucose in the urine occurs as the kidneys work to rid the body of the excess glucose.
Polyuria production of large amounts of urine develops as the glucose brings water along with it.
Polydipsia increased thirst caused by excessive urination
Polyphagia excess hunger caused by the inability to metabolize glucose
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