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lec 2
vi sinh
| Lymphocytes | are recognize antigens have specific receptors in their membranes ( B-cells & T-cells) |
| Naive | Have never encountered (gặp phải) foreign antigens Found in bloodstream and lymphoid Organs They are waiting for antigens |
| Effector T | Can eliminating foreign antigens: CD4 + "helper" T cells ( activate and help othe cells) CD8 + CTLs ( have cytoplasmic filled with proteins) |
| Effector B | Antibody secretly cells: Plasma Cell |
| memory cells | Survive in "resting", already encountered an antigen before |
| immunoglobulins (antibodies) structure | Y shape has: 1 FC (thân) 2 Fab (Antigen binding) |
| immunoglobulins found in | Free antibodies secreted by B Cell membrane of B (BCR) |
| T-cells receptor(TCR) | found in cell membrane of T |
| Differ between antibodies and TCR | Antibodies can recognize: any kind + free antigens TCR can recognize only: protein anti + anti that are bound inside MHC |
| MHC molecules | major histocompatibility complex molecules (vai trò cầu nối giữa T-cells vs antigen) |
| The cellular immune response function | Important in the elimination of: Cells infected with intracellular pathogens Tumoral cells Foreign human cells ( allogeneic) : tb ko thuộc host |
| immune response steps | Recognition antigens by naive cell Activation of cell Proliferation (sinh sôi) of cell Differentiation into effector cells (some memory cell) + T- cell: Migration (di chuyển) of effector to infection place + B- cell: Production of antibodies Elimina |
| CD4+ T cells | Helper cells interact with MHC class II (produce and release cytokines) |
| CD8+ T cells | interact with MHC class I |
| CD4+ T cells subsets | Th 0, Th 1, Th 2, Th 17, Tfh |
| Naive CD4+ T cells | TH 0 cell |
| TH 0 cell may differentiate in to Th1,2,17 | some will become other Th1, other Th2, other Th17 some become Tfh |
| TFH (T follicular helper cells) | cell do not migrate (di chuyển), help B all in the adaptive humoral immune response |
| Th1 cells function | against intracellular pathogens secretion of IFN gamma |
| Th2 cells function | help immune reactions mediated by IgE and mast cells against helmonths (worms) allergic reactions |
| Th17 cells function | destroy extracellular pathogen mainly by inducing inflammation (chủ yếu bằng cách gây viêm) |
| memory T-cell | live long CD4+ & CD8+ |
| T- cells contact the antigens twice | 1st naive T cell, 2nd effector T cell |
| humoral mean | non- cellular components of the blood |
| humoral immunity response | Mediated by secreted antibocties that produced by B cell |
| humoral immunity response type | T-independent (TI) antigens: can activate B cells directly T-depndent (TD) antigens: need help of some T cell |
| naive B cells surface has | IgM and IgD |
| TI responses produce only | IgM |
| TI antigens have | cell wall and capsule polysaccharides |
| Protein antigens | need help by T cell (Tfh) |
| plasma cells | not have BCR secrete large Ig migrate to the bone marrow |
| Primary response | Slow Antige is founded for the first time Naive B cells are activated IgM produced |
| Secondcay response | Faster and more effective Antigen is founded for the 2nd 3th... time Memory B are activated IgM < IgG, IgA, IgE produced |
| Secondcay response only produced agains | TD antigens (protein) |
| Primary response produced agains | all kind of antigens |
Created by:
huy12345
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