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Patholophysiology
| Question | Answer |
|---|---|
| Pathophys of VTE in pts with cancer | Tissue factor (TF) forms a complex with factor VII to activate factor IX and factor X, leads to coag. |
| Types of cancer in which tissue factor is seen: | sarcoma, melanoma, neuroblastoma, lymphoma, pancreatic ca, colorectal ca, ovarian ca (esp clear cell), APL |
| 4 types of diffusion across cell membranes | Mediated transport; facilitated diffusion; primary active transport; secondary active transport |
| 3 types of facilitated diffusion | ligand-gated, voltage-gated, mechanically-gated |
| Mechanism in mediated transport | transporter proteins change conformation |
| Distinction between primary and secondary active transport | Primary uses ATP (eg, the Na+/K+-ATPase pump), and secondary relies on electrochemical gradient |