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Path: Uterus

keep it simple

what pathology of the endometrium can present with bleedign virtually all of them
estrogen signals what phase proliferative
progesterone signals what phase secretory
what happens to the stroma during the secretory phase progesterone prevents it from shedding and it has a pseudodecidualized appearance
what does the stroma in post menopausal women look like dense but thin
what do oral contraceptive do to the glands and stroma glands are small and inactive and the stroma is predecidualized
most common cause of abnormal bleeding anovulation
what is the histiological explanation for dysfunctional uterine bleeding estrogen stimulation without subsequent progesterone to shed the lining
Acute endometriosis often s. aureus, strep or gonorrhea that occurs postpartum or post abortion (remaining placental parts)
histology of acute endometriosis neutrophils in stroma microabscess and filling gland lumens
Chronic endometriosis may be due to infections (chlam or gon) or trauma from IUD or leiomyomata emboli
histology of chronic endometriosis infiltrate of plasma cells not neutrophils like acute
endometrial Polyp common benign may cause irregular bleeding
what is an endometrial polyp histiologically dilated gland with fibrotic stroma and thick walled vessel
Adenomyosis when ENDOMETRIAL gland is found within the MYOMETRIUM
Endometrial Hyperplasia in perimenopausal women as a result of increased estrogen due to proliferation of the glands
when is endometrial hyperplasia considered to be premalignant when there is cellular atypia
Endometrial Adenocarcinoma 4th most frequent cancer in women with excess estrogen being the main association based on obesity, therapy, age of menopause, anovulation, tamoxifen)
what percent of patients with adenocarcinoma are postmenopausal 75%
who is the typical adenocarcinoma patient obese women with chronic anovulation (Polycystic ovarian disease) who is postmenopausal
most common type of adenocarcinoma endometrioid
Endometrioid Adenocarcinoma hyperplasial version of endometrial adenocarcinoma
Uterine papillary serous carcinoma worse prognosis atrophic version of endometrial adenocarcinoma
what is the difference in prognosis between endometroid and UPSC (adenocarcinomas of the endometrium) UPSC has a much worse prog. Endometroid have 90% 5 year with 75% presenting in stage 1
Leiomyomas benign fibroids MOST COMMON NEOPLASM IN WOMEN (25% of premenopausal)
how do leiomyomas appear whorled tan-white interlaces smooth muscle
Leiomyosarcomas Malignant mets to lung liver and brain within 2 years of diagnosis unlike leiomyomas they have focal hemorrhage necrosis and cytological atypia
Malignant Mixed Mullerian Tumor often in elderly women with polypoid mass coming from the endometrium and protruding through the cervix (poor prog - mix of leiomyosarcoma, rhabdomyosarcoma and osteosarcoma)
Created by: jmuame03