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ANA and other ABs

QuestionAnswer
Anti-ds-DNA (native DNA) SLE only (60%); an indicatore of disease activity and lupus nephritis
Anti histone Drug induced lupus (95%)
Anti centromer CREST
Anti-SM SLE only (25-30%)
Anti Ro (SSA) Sjogren; neonatal lupus
Anti LA (SSB) Sjogren
Anti RNP Mixed Connective Tissue Disease 100%
Anti glomerular basement membrane antibody Goodpasture
Scl-70 (anti-DNA topoisomerase 1): progressive systemic sclerosis; anti-centromere more in the localized form (CREST)
c-ANCA Wegener
p-ANCA PAN and Churg Strauss syndrome and Primary Sclerosing Cholangitis; Ulcerative colitis (50-80%)
Anti-Jo1 inflammatory myopathies
Anti Smith antibodies SLE specific
HLA-B27 Ankylosing spondylitis; also reactive and psoriatic arthritis
DR4 and DR1 Rheumatoid arthritis
DR3 Sjogren, SLE and also RA
Created by: Bijan39
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