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Hyperlipidemia II


SREBP-SCAP transcription factor increases LDL receptors
LXR-RXR increases conversion to bile, reverse transport, and SREBP1c so TGs are mde not cholesterol
FXR-RXR Increased bile export decreased synth
PPAR-alpha-RXR increase lipoprotein lipase (VLDL met) and increase fatty acid oxidation in the liver (decreased VLDL synth)
lipoprotein lipase recognizes? Apo CII
VLDL steals ? from HDL CE, APOC II-III and ApoE
how do small denses LDL form hepatic lipase removes more TGs from LDL
how is discoid HDL made ApoA I and II from the liver and the gut
how does HDL dock with the hepatocytes SRBI
ABC transport does? takes CE from the cells and gives it to HDL
what does CETP do? takes CE from HDL and gives it to VLDL and LDL
Created by: jmuame03