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Hyperlipidemia II
Stuff
| Question | Answer |
|---|---|
| SREBP-SCAP | transcription factor increases LDL receptors |
| LXR-RXR | increases conversion to bile, reverse transport, and SREBP1c so TGs are mde not cholesterol |
| FXR-RXR | Increased bile export decreased synth |
| PPAR-alpha-RXR | increase lipoprotein lipase (VLDL met) and increase fatty acid oxidation in the liver (decreased VLDL synth) |
| lipoprotein lipase recognizes? | Apo CII |
| VLDL steals ? from HDL | CE, APOC II-III and ApoE |
| how do small denses LDL form | hepatic lipase removes more TGs from LDL |
| how is discoid HDL made | ApoA I and II from the liver and the gut |
| how does HDL dock with the hepatocytes | SRBI |
| ABC transport does? | takes CE from the cells and gives it to HDL |
| what does CETP do? | takes CE from HDL and gives it to VLDL and LDL |