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MedChem II - stack 3
Catecholaminergic drugs part 2
| Drug name | Description |
|---|---|
| Phenoxybenzamine HCl (Dibenzyline) | Adrenergic antagonist, covalently bonds to the receptor, treats pheochromacytoma |
| Phentolamine (Regitine) | Incomplete and transient alpha-blocker, more potent than priscoline, used to treat pheochromacytoma |
| Priscoline (Tolazoline) | Less potent incomplete and transient alpha blocker, used in persistent pulmonary hypertension in newborn infants, use with caution in patients with gastritis or peptic ulcer disease |
| Prazosin HCl (Minipress) | Piperazinyl quinazoline alpha-antagonist, used in hypertension and benign prostatic hypertrophy |
| Terazosin HCl (Hytrin) | Piperazinyl quinazoline alpha-antagonist, highly specific for alpha-1 receptors, more water soluble (higher bioavailability, longer half-life, and duration of action) |
| Doxazosin mesylate (Cardura) | Piperazinyl quinazoline selective alpha-1 antagonist, treats hypertension |
| Afluzosin HCl (Uroxatral) | Piperazinyl quinazoline selective alpha-1 antagonist, metabolized by CYP3A4, used to treat BPH |
| Tamsulosin HCl (Flomax) | Non-piperazilyn quinazoline alpha-1 adrenergic antagonist, has a reduced incidence of vascular side effects, treats BPH, cannot be used to treat hypertension |
| Yohimbine | Indole alpha antagonist, has alpha-2 and serotonergic antagonist activity, used to treat impotence and postural hypotension |
| Propranolol HCl (Inderal) | Nonselective beta blocker, no sympathomimetic activity, lipophilic (CNS penetration, etc.), metabolized to naphtoxylactic acid, mainly used to treat hypertension |
| Nadolol (Corgard) | Analogue of propranolol, nonselective beta blocker with no intrinsic sympathomimetic activity, less lipophilic, treats hypertension and chest pain |
| Timolol maleate opthalmic solution (Timoptic) | Nonselective betea blocker, no sympathomimetic activity, lipophilic (systemic absorption), used to treat glaucoma |
| Timolol maleate oral (Blocadren) Combination with HCTZ (Timolide) | Oral form of timolol, marketed for hypertension |
| Pindolol (Visken) | Beta blocker with sympathomimetic activity, somewhat lipophilic, treats angina and hypertension |
| Labetalol HCl (Normodyne, Trandate) | Nonselective beta blocker, has some alpha-1 antagonistic activity, some sympathomimetic activity, treats hypertension |
| Metoprolol Tartrate (Lopressor) Metoprolol Succinate (Toprol XL) | Beta-1 selective antagonist, no intrinsic sympathomimetic activity, lipophilic, treats hypertension |
| Atenolol (Tenormin) | Beta-1 selective antagonist, no intrinsic sympathomimetic activity, less lipophilic, treats hypertension |
| Esmolol HCl (Bevibloc) | Beta-1 blocker with no intrinisc sympathomimetic activity, has a short half-life, used IV in emergencies involving atrial flutter, atrial fibrillation, or sinus tachycardia |
| Acebutolol HCl (Sectral) converted to Diacetolol | Beta-1 selective antagonist, diacetolol is the more active compound, has a degree of sympathomimetic activity |
| Carvedilol (Coreg) | S(-) isomer is a nonselective beta blocker, both enantiomers have alpha-blocking properties and thus vasodilatory activity, treats hypertension |
| Careolol (Cartrol) Penbutolol sulfate (Levatol) | Nonselective beta antagonists with intrinsic sympathomimetic activity |
| Levobunolol HCl (Betagan) | Nonselective beta blocker, used in treatment of glaucoma |
| Betaxolol HCl (Betopic) | Beta-1 selective antagonist, used as antihypertensive and in treatment of glaucoma |
| Bisprolol Fumarate (Zebeta) | Highly beta-1 selective antagonist, treats hypertension |
| Sotalol (Betapace) | Nonselective beta blocker, structurally distinct from others, treats ventricular arrhythmias |
| Propafenone HCl (Rythmol) | Weak beta blocker, has local anesthetic activity through blocking sodium ion channels, used as an antiarrhythmic |
| Nebivolol (Bystolic) | Highly selective beta blocker (selects beta-1 over beta-2), less bronchoconstrictive effects, treats hypertension |
| Theophylline Aminophylline | Inhibit phosphodiesterase enzyme and prevent conversion of c-AMP to 5`-AMP, cause bronchodilation |
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