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Micro 7-1

Duke PA micro

Bordetella - gram negative or positive gram negative coccobacilli
Bordetella - aerobic or anaerobic? strictly aerobic
How many known species of Bordetella? 7 species
Which species of Bordetella is a stictly human pathogen? B. pertussis
B. pertussis - etiologic agent of what? whooping cough
B. pertussis - lab specimens? care must be taken - call lab
What do the two other species of Bordetella cause? milder bronchopulmonary disease
Virulence factors of Bordetella protein adhesins, toxins
Campylobacter spp. Gram negative or positive? comma shaped Gram negative bacillus
How many species of Campylobacter spp? 16, most associated with human disease
Campylobacter disease? mostly gastroenteritis, sepsis, sponatenous abortion
Campylobacter oxygen requirements microaerophilic; need small amount of CO2
Natural reservoirs for Campylobacter? animals
Route of infection of humans with Campylobacter ingestion of contaminated food, milk, or water; also fecal/oral route
Virulence factors of Campylobacter adhesins, cytoxic enzymes, and enterotoxin but their exact roles in vivo not clearly understood
Most common cause of bacterial gastroenteritis in USA? Campylobacter jejuni
Who is at risk for infeciton with Campylobacter jejuni? ingestion of large numbers of organisms or those lacking in gastric acid
Distribution and incidence of C. jejuni in different types of weather world wide distribution, increased incidence in warm weather
Treatment for C. jejuni infections disease is usually self-limiting, but antibiotic therapy is given for severe infections
Capnocytophaga canimorsus gram negative or positive? fastidious Gram negative bacillus
First name of Capnocytophaga canimorsus given by CDC in 1984 dysgonic fermenter (DF)
Capnocytophaga canimorsus normal flora found in respiratory tract and saliva of human (DF-1) and dogs/cats (DF-2)
Capnocytophage canimorsus is a common cause of what kind of infections? human bite infections
How severe is infection with capnocytophaga canimorsus? mild to deadly - immunosuppression increases risk - asplenic patients can have severe sepsis
Eikenella corrodens gram negative or positive? small, fastidious Gram negative bacillus; corrodes agar medium
What does Eikenella corrodens smell like as it grows? bleach
Eikenella corrodens normal flora upper respiratory tract of humans
eikenella infection implicated in bite infections; endocarditis in patients with pre-existing heart disease
Eikenella risk? risk of serious complications in patients who are immunocompromised
Eikenella belongs to which group? HACEK
What is the most diverse group of medically important, gram negative, medium-sized bacilli Enterobacteriaceae
Number of genera and species of Enterobacteriaceae >40 genera, >150 species
Route of infection - enterobacteriaceae via animal reservoir, human carrier, or endogenous - many are opportunistic, nosocomial
As a group account for 1/3 of all septicemias and 2/3 of all UTIs Enterobacteriaceae, but only ~20 species account for nearly all infections
study from slide 10 on
Created by: ges13