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Ch.18
Drug Abuse
Term | Functions |
---|---|
Neural Basis of Reinforcing Effects of Opiates | pain tolerance, hypothermia, sedation, Increases dopamine production in the NAC by 150-300% |
Opiates | Significant tolerance, Exposure to unsanitary instruments, Crosses placenta, Toxicity of diluting substances and uncertain strength of batch |
In cocaine-dependent men | correlations between drug-cue related craving and activation: observed (in the hippocampus, insula, and anterior and posterior cingulate) |
In cocaine-dependent women | correlations between drug-cue related craving and activation: observed (in the hippocampus, insula, orbitofrontal cortex, putamen, and midbrain) |
In cocaine-dependent men | subjective level of drug-induced craving - positive correlation with drug cue condition-related corticostriatal-limbic activation |
In cocaine-dependent women | subjective level of stress induced craving - positive correlation with stress cue condition-related corticostriatal-limbic activation |