Busy. Please wait.
Log in with Clever

show password
Forgot Password?

Don't have an account?  Sign up 
Sign up using Clever

Username is available taken
show password

Make sure to remember your password. If you forget it there is no way for StudyStack to send you a reset link. You would need to create a new account.
Your email address is only used to allow you to reset your password. See our Privacy Policy and Terms of Service.

Already a StudyStack user? Log In

Reset Password
Enter the associated with your account, and we'll email you a link to reset your password.
Didn't know it?
click below
Knew it?
click below
Don't Know
Remaining cards (0)
Embed Code - If you would like this activity on your web page, copy the script below and paste it into your web page.

  Normal Size     Small Size show me how

Renal 2

How does urea reabsorption work? Urea drags water from CD into interstitium. Low water intake leads to ADH increasing activity of apical UT transporters
Where does urea reabsorption occur? Collecting duct
Where does bicarbonate reabsorption occur? 85%-90% reabsorbed in the PCT 0-5% in the DCT
How does bicarbonate reabsorption in the PCT work? Hydrogen leaves the cell via H+ ATPase, and the Na/H+ antiporter Bicarbonate crosses the basolateral side via Na/HCO3- symporter
How does bicarbonate reabsorption in the DCT work? H+ secretion by the intercalated cell H+ ATPase HCO3- crosses basolateral membrane via HCO3-/Cl- exchanger
Explain ammonia formation (NH3) and its role is acid balance PCT synthesizes NH3 from glutamine. It accepts H+ to form ammonium NH4+ in the tubular fluid. Renal tubules are impermeable to ammonium, so it is excreted
What is GFR? Tells you how well your kidneys are filtering
How is GFR measured? GFR = UV/P
Why is inulin used in GFR measurement? it is not reabsorbed by kidneys or secreted back by peritubular capillaries
What is involved in the juxtaglomerular apparatus? Macula densa of DCT, Juxtaglomerular cells, and Extraglomerular mesangial cells
Explain the tubuloglomerular autoregulation mechanism Macula densa cells sense the levels of Na in the fluid. It releases prostaglandin which stimulates the hormonal system, and NO, that vasodilates the afferent arteriole
Explain how the hormonal regulation works Granular cells are stimulated by prostaglandins and activation of beta 1 receptors. This triggers renin release that produces angiotensin 2
What does angiotensin 2 do? Vasoconstrict efferent, release aldosterone, ADH, increases catecholamine release
How does the myogenic regulation work? Blood pressure is monitored. With a drop of BP, calcium channels close, leading to a vasodilation of the afferent.
How does macula densa cell control vasodila/constriction? Ca2+
Describe the neural mechanism for autoregulation BP is monitored by baroreceptors that activates the Sympathetic nervous system
Describe the RAAS system
What does aldosterone do? Acts on principle cells of DCT and CD by upregulating basolateral NaK ATPase. Upregulates ENaCs in CD and colon Stimulate secretion of H+ by H+ ATPase in intercalated cells of cortical CD
What does ADH do? Increase transcription of AQP2 by cAMP activation of protein kinase A. Increase Na uptake. Increase Urea uptake in CD by regulating expression of UT. V1 receptor in smooth muscle (vascular) vasoconstriction
What epithelial cell type can be found in the PCT? Squamous cuboidal epithelium
What epithelial cell type can be found in the Ascending loop? Simple cuboidal epithelium
What do principle cells do? Secrete K+ and absorb Na+
Plasma concentration of K+ triggers what hormone? Aldosterone
What has no effect on GFR? ADH
Where is the vasa recta found? Juxtamedullary nephrons
What allows urea into the LOH? UT-B
Aldosterone targets which cells? Principle cells in renal CD epithelium
What does ANP do? It dilates the afferent and constricts the efferent.Increases blood flow through the vasa recta, which will wash the solutes out of the medullary interstitium, leads to less reabsorption of tubular fluid and increased excretion. Inhibits renin secretion,
ANP is stimulated by? Increased cardiac distention, Sympathetic activity, Angiotensin 2 and exercise
ANP is produced by? Cardiac myocytes
Created by: lijingsaw
Popular Medical sets




Use these flashcards to help memorize information. Look at the large card and try to recall what is on the other side. Then click the card to flip it. If you knew the answer, click the green Know box. Otherwise, click the red Don't know box.

When you've placed seven or more cards in the Don't know box, click "retry" to try those cards again.

If you've accidentally put the card in the wrong box, just click on the card to take it out of the box.

You can also use your keyboard to move the cards as follows:

If you are logged in to your account, this website will remember which cards you know and don't know so that they are in the same box the next time you log in.

When you need a break, try one of the other activities listed below the flashcards like Matching, Snowman, or Hungry Bug. Although it may feel like you're playing a game, your brain is still making more connections with the information to help you out.

To see how well you know the information, try the Quiz or Test activity.

Pass complete!
"Know" box contains:
Time elapsed:
restart all cards