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Microcirculation M
Microcirculation - Guyton
Question | Answer |
---|---|
How does the transport over capillary membrane occure? | Through intercellular cleft (glucose, Na,Cl), diffusion (through the cell membrane O2,Co2) and ((vesicle transport)). |
What is the difference between capillaries in brain, liver, kidney and gi canal? | Brain has more tight junctions->only small molecules enters(O2,Co2, H2O), Liver cleft is wide open->plasma protiens can enter, kidney (glomerular)->fenestrae allow tremendous amount of small and ionic substances to pass through (but not plamsa protiens. |
What is vasomotion? | Turning the sphincter on and off in arterioles and metarterioles produces a acountinuously flow. |
How is vasomotion regulated? | Low [O2]->longer duration and higher frequency on vasomotion. |
What is the meaning of average function of capillary system? | That we have 1)average rate of blood flow and capillary pressure 2)Average rate of transport through the capillaries. |
What is diffusion? | Diffusion is a result from thermal motion of fluid and dissolved substances in the fluid. |
What is the interstitum? | The space between the cells. And the fluid is called interstitial fluid. |
What do we have between the cells in the intersitium? | We have 1) collagen fibers->tensional strenght 2)proteoglycans->fluid cant flow thorough. |
What is the gel in the interstitium? | Its the filtered fluid from capillaries. It has almost the same constituents as plasma but has less protiens. |
Why does 99% of the fluid diffuse in the interstitium? | Because of proteoglycans. In edema the fluid flow instead of diffusing because of the higher concentration of water. |
The filtration through the capillaries is determined by? | 1)hydrostatic pressure 2)colloid pressure 3)capillary filtration coefficiens. |
Describe the starling forces. | 1) Pc, capillary pressure 2)Pif - interstitial pressure 3)colloid osmotic pressure 4)interstitial fluid colloid osmotic pressure. |
What is the net filtration pressure? | Ntp=outward - inward= net outward pressure |