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Epilepsy

Anti-Epileptic Drug Interactions

QuestionAnswer
Carbamazepine (S, I) Substrate: 3A4; Inducer: CYP, UGT, P-GP (potent)
Clobazam (S, I) Substrate: 3A4, 2C19; Inhibits: 2D6 (moderate)
Eslicarbazepine (I) Inhibits: 2C19 (moderate)
Ethosuximide (S) Substrate: 3A4
Lamotrigine (S, I) Substrage: UGT; Induces: UGT (minor)
Oxcarbazepine (I) Induces: 3A4 (moderate to severe)
Phenobarbital (S, I) Substrate: 2C19; Induces: CYP, UGT (potent)
Phenytoin (S, I) Substrate: 2C9; Induces: CYP, UGT (potent)
Primidone (S, I) Substrate: 2C19; Inducer: CYP (potent)
Tiagabine (S) Substrate: 3A4
Valproate (S, I) Substrate: CYP; Inducer: CYP, UGT (moderate)
Vigabatrin (I) Induces: 2C9
Zonisamide (S) Substrate: 3A4
Brivaracetam None
Ezogabine None
Felbamate None
Gabapentin None
Lacosamide None
Levetiracetam None
Perampanel (I) Induces: progestin containing contraceptives
Pregabalin None
Rufinamide None
Topiramate None
Created by: kornblum
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