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Epilepsy

Anti-Epileptic MOAs

QuestionAnswer
Benzodiazepines +++ inhibitory transmission through GABA
Brivaracetam +++ SV2A
Carbemazepine +++ Na channels, + Ca channels
Clobazam +++ inhibitory transmission
Ethosuximide +++ Ca channels
Felbamate ++ Na channels, + Ca channels, ++ inhibitory transmission, ++ excitatory transmission
Gabapentin + Na channels, + Ca channels, ++ inhibitory transmission
Lacosamide +++ Na channels
Lamotrigine +++ Na channels, + Ca channels
Levetiracetam + Ca channels, + K channels, + inhibitory transmission, + excitatory transmission, +++ Sv2A
Oxcarbazepine +++ Na channels, + Ca channels, + K channels
Perampanel +++ excitatory transmission
Phenobarbital + Ca channels, +++ inhibitory channels, + excitatory channels
Phenytoin +++ Na channels, + Ca channels
Rufinamide +++ Na channels
Tigabine +++ inhibitory transmission
Topiramate ++ Na channels, ++ Ca channels, ++ inhibitory transmission, ++ excitatory transmission
Valproate + Na channels, + Ca channels, ++ inhibitory transmission, + excitatory transmission
Vigabatrin +++ inhibitory transmission
Zonisamide ++ Na channels, ++ Ca channels
Created by: kornblum
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