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Antibiotics Micro
WVSOM -- Immuno/Micro -- Antibiotic List
Question | Answer |
---|---|
D-cycloserine | Cell wall synthesis; blocks addition of dipeptide to UDP-NAM - second step so no PEP attaches |
Bacitracin | cell wall synthesis; blocks dephosphoralizatoin of bactoprenol phosphate- middle step transports ppg monomers across cell membrane |
PCN | cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links |
Cephalosporin | cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links |
cephamycin | cell wall synthesis |
fosfomycin | inhibits cell wall synthesis; inhibits phosphoenopyruvate transferase adn prevents formation of NAM -- first step does not occur |
metronidazole | disrupts DNA helical structure under anaerobic conditions |
Quinolones, flouroquinolones | inhibits DNA gyrase or topoisomerase |
rifampin | binds to RNA polymerase |
polymyxins | interact with phospholipids |
macrolides, erythromycin, choramphenicol | 50S inhibitors; translation-protein synthesis |
tetracyclines, aminoglycosides, streptomycin | 30S inhibitors; translation-protein synthesis |
Linezolid | initiating complex blocked; |
sulfonamides | folate antagonist; blocks synthesis of dihydropteroic acid |
trimethoprim | folate antagonist; blocks synthesiss of tetrahydrofolate |