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Antibiotics Micro

WVSOM -- Immuno/Micro -- Antibiotic List

QuestionAnswer
D-cycloserine Cell wall synthesis; blocks addition of dipeptide to UDP-NAM - second step so no PEP attaches
Bacitracin cell wall synthesis; blocks dephosphoralizatoin of bactoprenol phosphate- middle step transports ppg monomers across cell membrane
PCN cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links
Cephalosporin cell wall synthesis; beta-lactamases; last step of binding to transpeptidase to reform the peptide cross links
cephamycin cell wall synthesis
fosfomycin inhibits cell wall synthesis; inhibits phosphoenopyruvate transferase adn prevents formation of NAM -- first step does not occur
metronidazole disrupts DNA helical structure under anaerobic conditions
Quinolones, flouroquinolones inhibits DNA gyrase or topoisomerase
rifampin binds to RNA polymerase
polymyxins interact with phospholipids
macrolides, erythromycin, choramphenicol 50S inhibitors; translation-protein synthesis
tetracyclines, aminoglycosides, streptomycin 30S inhibitors; translation-protein synthesis
Linezolid initiating complex blocked;
sulfonamides folate antagonist; blocks synthesis of dihydropteroic acid
trimethoprim folate antagonist; blocks synthesiss of tetrahydrofolate
Created by: tjamrose