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Immunity RA SLE
Immunity lecture
Question | Answer |
---|---|
Symptoms of SLE? | Protean: kidney, brain, heart, skin, joints |
Triggers of SLE? | EBV, retrovirus |
What are the autoimmune complexes of SLE? | anti-Ro,-La,-Sm,-RNP,-histone,-dsDNA, |
Pathology of SLE? | Immune comlex mediated inflammation and tissue damage |
What are the complications of SLE? | Premature atherosclerosis, infection |
What are the symptoms of RA? | symmetrical pain, swelling, deformities of joints, morning stiffness, nodules |
What are the triggers of RA? | EBV, smoking |
What are the complications of RA? | Premature atherosclerosis, vasculititis |
What is the trigger of systemic autoimmune disease? | Antigen (DNA, Ro, La, SM, RNP, Phospholipid) + Adjuvant = Immune response (innate) -> Adaptive immune response |
What are the determinants of SLE? | Genes, Environment, Chance |
How do they hypothesize that SLE is triggered? | Virus -> alpha IFN -> Production of Ro + Innate immune response (increase MHC production on cells) -> Anti-Ro Autoantibodies (Immune complex) |
What do the endogenous and exogenous ligands do in SLE? | They activate TLR and increase IFN alpha production. |
What impact of IFN alpha on dendritic cell maturation and class switiching have on disease SLE? | Autoimmunity |
What impact does IFN gamma and chemokines as well as the destruction of endothelial progenitors have on the disease (SLE)? | inflammation and tissue damage |
What are some general approaches to therapy of SLE? | Block CD28, CD40 on T cells; Cytokines; TLR, B cell targeting, complement system |
Which 2 cytokines are heavy in RA? | TNF alpha and IL1 |
What are some things that you didn't know about TNF in RA? | Induces proinflam production, Promotes synoviocyte activation, maintiains inflammatory state in synovial membrane, induces osteoclast differentiation |
What is the major costimulation in the adaptive immune system in RA? | CD40/CD40L; B7/CD28; |