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Pharm Final - Drug Side Effects

Adverse effects of Beta-blockers Impotence, asthma, cardiovascular effects (bradycardia, CHF, AV block) and CNS effects (sedation, sleep alterations)
Adverse effects of Captopril/Enalapril/Fosinopril Hyperkalemia, cough, angioedema, taste changes, hypotension, pregnancy problems (fetal renal damage), rash and increased renin
Adverse effects of Clonidine Dry mouth, sedation and severe rebound hypertension
Adverse effects of Diazoxide Hyperglycemia (reduces insulin release, hypotension)
Adverse effects of Guanethidine Orthostatic and exercise hypotension, dizziness and headache
Adverse effects of Hydrazaline Nausea, headache, lupus-like syndrome, reflex tachycardia, angina and salt retention
Adverse effects of Hydrochlorothiazide Hypokalemia, mild hyperlipidemia, lassitude, hypercalcemia and hyperglycemia
Adverse effects of Loop diuretics Potassium wasting, metabolic alkalosis, hypotension and ototoxicity
Adverse effects of Losartan Fetal renal toxicity and hyperkalemia
Adverse effects of Methyldopa Sedation and positive Coombs' test
Adverse effects of Minoxidil Hypertrichosis, pericardial effusion, reflex tachycardia, angina and salt retention
Adverse effects of Nefedine and verapamil Dizziness, flushinig, constipation (Verapamil), nausea and edema
Adverse effects of Nitroprusside Cyanide toxicity (releases CN)
Adverse effects of Prazosin 1st dose orthostatic hypotension, dizziness and headache
Adverse effects of Reserpine Sedation, depression, nasal stuffiness and diarrhea
Antibiotics that are toxic in pregos Sulfonamides (kernicterus), aminoglycosides (ototoxicity), fluoroquinolones, erythromycin, metronidazole, tetracyclines (discolored teeth, inhibition of bone growth), ribavirin, griseofulvin, chloramphenicol (gray baby) and clarithromycin
Factors that increase digoxin toxicity Renal failure (decreased excretion), hypokalemia (digoxin competes with K+ at its binding site in Na+/K+ ATPase) and quinidine (decreased digoxin clearance).
P450 Inducers Quinidine, Barbiturates, St. John's wort, Phenytoin, Rifampin, Griseofulvin and Carbamazepine
P450 inhibitors Sulfonamides, isoniazid, cimetidine, ketoconazole, erythromycin, grapefruit juice
SE: Acute cholestatic hepatitis (1) Macrolides
SE: Agranulocytosis (5) Clozapine, carbamazepine, colchicine, propylthiouracil (PTU) and methimazole
SE: Angioedema (1) ACE inhibitors (Captopril)
SE: Aplastic anemia (8) Chloramphenicol ("like pouring chlorine down your femur"), benzene, NSAIDs, propylthiouracil (PTU), methimazole and alkylating agents (cyclophosphamide, carmustine and cisplatin)
SE: Asthma (1) Aspirin and other salicyclates
SE: Atropine-like (1) Tricyclics
SE: Cholestasis (3) Oral contraceptives, estrogen and anabolic steroids
SE: Cinchonism (2) Quinidine and quinine
SE: Coronary vasospasm (2) Cocaine and sumatriptan
SE: Cough (1) ACE inhibitors (Captopril, Lisinopril) - Note: ARBs like Losartan do not have a cough side effect
SE: Cutaneous flushing (4) Niacin, calcium channel blockers, adenosine and vancomycin
SE: Diabetes insipidus (2) Lithium and demeclocycline
SE: Dilated (congestive) cardiomyopathy (3) Doxorubicin, daunorubicin and cocaine
SE: Direct Coombs-positive hemolytic anemia (1) Methyldopa
SE: Disulfiram-like reaction (4) Metronidazole, certain cephalosporins, procarbazine and 1st-generation sulfonylureas
SE: Fanconi's syndromes Expired tetracycline
SE: Focal to massive hepatic necrosis (4) Halothane, valproic acid, acetaminophen (most common), Amanita phalloides, salicylates and iron
SE: Gingival hyperplasia (1) Phenytoin
SE: Gout (2) Furosemide and thiazides
SE: Gray baby syndrome (1) Chloramphenicol
SE: Gynecomastia Spirinolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole (Some Drugs Create Awesome Knockers)
SE: Hemolysis in G6PD-deficient patients (6) Isoniazid (INH), Sulfonamides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin (hemolysis IS PAIN)
SE: Hemolytic anemia (3) Penicillin, methyldopa and quinidine
SE: Hemorrhagic cystitis (2) Cyclophosphamide and ifosfamide (prevent by coadministrating with mesna)
SE: Hemorrhagic gastritis (2) Iron and salicylates (Aspirin)
SE: Hepatic adenoma (1) Oral contraceptives
SE: Hepatic fatty changes (3) Amiodarone, tetracycline and methotrexate
SE: Hepatitis (1) Isoniazid (INH)
SE: Hot flashes (2) Tamoxifen and clomiphen
SE: Interstitial nephritis (3) Methicillin, NSAIDs and furosemide
SE: Maculopapular rash (1) Penicillin
SE: Megaloblastic (macrocytic) anemia (5) Phenytoin, Methotrexate (most common) and Sulfa drugs (having a BLAST with PMS) - also with oral contraceptives and 5-fluorouracil
SE: Nephrotoxicity/neurotoxicity Polymyxins
SE: Nephrotoxicity/ototoxicity Aminoglycosides (Gentamycin), vancomycin, loop diuretics and cisplatin
SE: Osteoporosis (2) Corticosteroids and heparin
SE: Parkinson-like syndrome (4) Haloperidol, chlorpromazine, reserpine and metoclopramide
Se: Photosensitivity (3) Sulfonamides, Amiodarone and Tetracycline (most common) (SAT for a photo)
SE: Platelet dysfunction (2) Aspirin and other NSAIDs
SE: Pseudomembranous colitis (2) Clindamycin and ampicillin
SE: Pulmonary (interstitial) fibrosis (4) Bleomycin (most likely to cause), bulsulfan, amiodarone, methotrexate and nitrofurantoin
SE: Rash (Stevens-Johnson syndrome) (8) Ethosuximide, lamotrigine, carbamazepine, phenobarbital, phenytoin, sulfa drugs, penicillin and allopurinol
SE: Seizures (3) Bupropion, imipenem/cilastatin and isoniazid
SE: SLE-like syndrome (4) Hydrazaline, INH, Procainamide and Phenytoin (it's not HIPP to have lupus)
SE: Tardive dyskinesia Antipsychotics
SE: Tendonitis, tendon rupture and cartilage damage (kids) Fluoroquinolones (hurts attachments to your bones)
SE: Thrombocytopenia Heparin (most common) and quinidine
SE: Thrombotic complications (2) OCPs (estrogens and progestins)
SE: Tinnitus and vertigo (1) Salicylates
SE: Torsades de pointes (3) Sotalol (class 3) and quinidine (class 1) antiarrhythmics and cispride
SE: Urticaria (1) Penicillin
SE:Adrenocortial insufficiency (1) Glucocorticoid (Prednisone) withdrawal (HPA suppression)
SEs of 5-fluoruracil Myelosupression, which is NOT reversible with leucovorin, and photosensitivity
SEs of Azathioprine Bone marrow suppression. Active metabolite mercaptopurine is metabolized by xanthine oxidase; thus, toxic effects may be increased by allopurinol.
SEs of Bleomycin Pulmonary fibrosis, skin changes, but minimal myelosupression
SEs of Carmustine CNS toxicity (dizziness, ataxia)
SEs of Cisplatin and Carboplatin Nephrotoxicity and acoustic nerve damage
SEs of Clomiphene Hot flashes, ovarian enlargement, multiple simultaneous pregnancies and visual disturbances
SEs of Cyclophosphamide Myelosuppression, hemorrhagic cystitis (can be partially prevented with Mesna)
SEs of Cyclosporine Nephrotoxic preventable with mannitol
SEs of Cytarabine Leukopenia, thrombocytopenia and megaloblastic anemia
SEs of Doxorubicin and Daunorubicin Cardiotoxicity, myelosupression and marked alopecia
SEs of Estrogens Increased risk of endometrial cancer, bleeding in postmenopausal and increased risk of thrombi
SEs of Imatinib Fluid retention
SEs of Imipenem GI distress, skin rash and CNS toxicity (seizure) at high plasma levels
SEs of Leuprolide Antiandrogen, nausea and vomiting
SEs of Macrolides GI discomfort (most common cause of noncompliance), acute cholestatic hepatitis, eosinophilia and skin rashes
SEs of Methotrexate Myelosuppression (reversible with leucovorin rescue), macrovesicular fatty change in the liver and mucositis
SEs of Mifepristone Heavy bleeding, GI effects (nausea, vomiting, anorexia) and abdominal pain
SEs of OKT3 Cytokine release syndrome and hypersensitivity reaction
SEs of Paclitaxel Myelosuppression and hypersensitivity
SEs of Prednisone Cushing-like symptoms; immunosuppression, cataracts, acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia and psychosis
SEs of Sildenafil Headache, flushing, dyspepsia, impaired blue-green color vision; risk of life-threatening hypotension in patients taking NITRATES
SEs of Sirolimus Hyperlipidemia, thrombocytopenia and leukopenia
SEs of Tacrolimus Nephrotoxicity, peripheral neuropathy, hypertension, pleural effusion and hyperglycemia
SEs of Tamoxifen May increase the risk of endometrial carcinoma via partial agonist effects; "hot flashes"
SEs of Trastuzumab Cardiotoxicity
SEs of Trimethoprim (TMP) Megaloblastic anemia, leukopenia and granulocytopenia
SEs of Vincristine Neurotoxicity (areflexia, peripheral neuritis), paralytic ileus
Sulfa drugs Celecoxib, furosemide, probenecid, thiazides, TMP-SMX, sulfasalazine, sulfonylureas and sumatriptan
Symptoms of sulfa drug allergies Fever, pruritic rash, Stevens-Johnson syndrome, hemolytic anemia, thrombocytopenia, agranulocytosis and urticaria (hives)
Created by: megankirch