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FSHN 450-3 Trsplants
| Question | Answer |
|---|---|
| Autologous | bone marrow or stem cells from host |
| Allogenic | bone marrow/stem cells or organ from donor |
| Xenogenic | organ from different species (ethical/rejection issues) |
| Humoral response | antibodies |
| Cell-mediated response | T-cells |
| 5 mechanisms of anti-rejection drugs | purine synthesis, inhibit cytokine production, inhibit binding, inhibit T-cell activation, suppress T-cell maturation or proliferation |
| organ matching | blood type, antibodies, MHC |
| what juice to avoid with immunosuppressive drugs? | grapefruit |
| cardiac cachexia | hypermetabolic, congestion/edema, eating increases O2 req |
| LVAD | left ventricular assist device (increases QOL when waiting for heart/lung transplant) |
| Primary biliary cirrhosis | immune system attacks bile ducts |
| Sclerosing cholangitis | scarring and narrowing of bile ducts inside and outside of liver |
| Biliary atresia | malformation of the bile ducts |
| Wilson’s disease | abnormal levels of copper in liver |
| Hemochromatosis | accumulation of iron in liver |
| Vascular anastomosis | connecting vasculature during transplants |
| Protein kidney/liver vs. others | less to not ruin new organs |