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BCLT 4-2 Mono
Infectious Mono Tests
Term | Definition |
---|---|
infectious mononucleosis | "mono" "kissing disease", caused by epstein-barr virus (EBV), transmission: saliva, latent (dormant), 50% with virus>>actually get mono, 15-24 y/o, 95% adults have EBV by 40 y/o |
based on 1,2,3 >> incubation period ? | based on clinical symptoms, hematological findings, immunological test results >> incubation period = 4-6 weeks before detectable |
clinical symptoms | fever, sore throat, fatigue, lymphadenopathy, hepatosplenomegaly |
hematological findings | lymphocytosis, atypical/reactive lympnocytes |
immunological test results | detect heterophile antibodies (specifically assoc. with IM and peak 2-4 weeks) |
immuno-chromato-graphic | color changes due to antibody and antigen reactions |
CLIA waived with | whole blood |
Immunochromatographic test principles | qualitative test, bovine RBC antigen particles coat test strip membrane, color change in testing area appears w/ pos reaction=IM heterophile antibodies present |
procedure | sample >> sample well >> developer solution >> sample migrates across testing strip membrane >> read results 5 min |