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P21-22 NSAID
Term | Definition |
---|---|
Local Responses in Inflammation | • Pain • Heat • Redness • Swelling • Loss of function |
Anti-Inflammatory Drugs - therapeutic strategies | • Inflammation (anti-inflammation) • Pain (analgesia) • Fever (antipyrexia) |
Acute Inflammatory Reaction | • Innate immune response - rapid, release cytokines, direct: phagocytosis, anitimicrobial activity • Adaptive immune response - slow, recognition, gene rearrangement, response: T & B cells with receptors encoded by fully rearranged genes |
Abnormal Immune Responses | Extensive tissue damage (hypersensitivity), Reactivity against self antigens (autoimmunity), Impaired reactivity to appropriate targets (immunodeficiency) |
Biological Effects of Eicosanoids - at site of inflammation | • Dilate precapillary arterioles --> increse blood flow --> redness • Cause greater increase in permeability of postcapillary venules induced by histamine and bradykinin --> swelling • Potentiate pain production by bradykinin |
classifications (x5) | SPAOF 1. Salicylates 2. Proprionic acids 3. Acetic acids 4. Oxycams 5. Fenamates |